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首页> 外文期刊>Cell cycle >The double life of the Ku protein: facing the DNA breaks and the extracellular environment.
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The double life of the Ku protein: facing the DNA breaks and the extracellular environment.

机译：Ku蛋白的双重寿命：面对DNA断裂和细胞外环境。

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摘要

The Ku heterodimer (Ku70/Ku80) plays a central role in DNA double strand break recognition and repair. It has been shown, more than ten years ago, that Ku is also expressed at the cell surface of different cells types along with its intracellular pool within the nucleus and the cytoplasm but involvement of Ku in cell-cell and cell-extracellular matrix adhesion has been only recently demonstrated. In addition, we have shown that Ku may have a second and unexpected activity in cell/microenvironment interaction. Indeed, Ku appears to be involved in extracellular proteolytic processes through its specific interaction, on the cell surface, with the matrix metalloprotease 9. Taken together, these results suggest that Ku function at the cell surface is likely to be important in tumour invasion. Various fundamental questions arise from these observations. How Ku is expressed on the cell surface, why a protein with completely unrelated functions also serve as an integrin-like molecule once expressed at the cell surface and is this functional moonlighting of Ku related to cell transformation remain open issues that will be discussed here.
机译：Ku异二聚体（Ku70 / Ku80）在DNA双链断裂识别和修复中起着核心作用。十多年前，研究表明，Ku还在细胞和细胞质内的细胞内池中以及在不同细胞类型的细胞表面表达，但Ku参与细胞与细胞和细胞与细胞外基质的粘附直到最近才被证明。另外，我们已经表明，Ku在细胞/微环境相互作用中可能具有第二种和意想不到的活性。实际上，Ku似乎通过其在细胞表面与基质金属蛋白酶9的特异性相互作用而参与了细胞外蛋白水解过程。综上所述，这些结果表明，Ku在细胞表面的功能可能在肿瘤侵袭中很重要。这些观察结果提出了各种基本问题。 Ku如何在细胞表面表达，为什么具有完全不相关功能的蛋白质一旦在细胞表面表达后还能起整合素样分子的作用，Ku的这种功能性月光与细胞转化有关仍然是悬而未决的问题，将在这里进行讨论。

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