Meisetz, a novel histone tri-methyltransferase, regulates meiosis-specific epigenesis.

Hayashi K; Matsui Y

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Meisetz, a novel histone tri-methyltransferase, regulates meiosis-specific epigenesis.

机译：Meisetz，一种新型的组蛋白三甲基转移酶，调节减数分裂特异的表观遗传。

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Meiosis is a specialized cell division that is essential to reduce the ploidy of the genome and to generate genomic diversity in all sexually reproducing organisms. Our recent investigation revealed that the meiosis-specific histone methyltransferase Meisetz (Meiosis-induced factor containing PR/SET domain and zinc-finger motif) played an essential role on proper progression of meiotic prophase in mouse germ cell lineage. The finding also suggests that the germ cell lineage has a meiosis-specific epigenetic status that is different from that of the somatic cell lineage. This article reviews the function of Meisetz and prospects the epigenetic background allowing proper progression of meiosis in mouse germ cells.

机译：减数分裂是一种专门的细胞分裂，对于减少基因组的倍性和在所有有性生殖生物中产生基因组多样性至关重要。我们最近的研究表明，减数分裂特异的组蛋白甲基转移酶Meisetz（含有PR / SET域和锌指基序的减数分裂诱导因子）在小鼠生殖细胞谱系中减数分裂前期的正常进程中起着至关重要的作用。该发现还表明生殖细胞谱系具有与体细胞谱系不同的减数分裂特异性表观遗传状态。本文回顾了Meisetz的功能，并展望了表观遗传背景允许小鼠生殖细胞中减数分裂的适当进展。

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《Cell cycle》 |2006年第6期|共6页
作者
Hayashi K; Matsui Y;
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正文语种 eng
中图分类细胞生物学;
关键词
Cell Lineage; Epigenesis; Genetic; Germ Cells; Histone-Lysine N-Methyltransferase; 细胞谱系; 生殖细胞; 组蛋白类; 减数分裂;

机译：Cell Lineage;Epigenesis;Genetic;Germ Cells;Histone-Lysine N-Methyltransferase;细胞谱系;生殖细胞;组蛋白类;减数分裂;

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专利

1. 动物组蛋白H3K4三甲基化转移酶MLL3的生物信息学分析 [J] . 尚明保, 杨旬旬, 吴风瑞, 农业科学与技术（英文版） . 2012,第003期
2. Meisetz, a novel histone tri-methyltransferase, regulates meiosis-specific epigenesis. [J] . Hayashi K, Matsui Y Cell cycle . 2006,第6期

机译：Meisetz，一种新型的组蛋白三甲基转移酶，调节减数分裂特异的表观遗传。
3. Glucose and Nitrogen Regulate the Switch from Histone Deacetylation to Acetylation for Expression of Early Meiosis-Specific Genes in Budding Yeast [J] . Lilach Pnueli, Iris Edry, Miriam Cohen, Molecular and Cellular Biology . 2004,第12期

机译：葡萄糖和氮气调节从组蛋白脱乙酰向乙酰化的转变，用于芽胞酵母中早期减数分裂特异性基因的表达
4. Glucose and Nitrogen Regulate the Switch from Histone Deacetylation to Acetylation for Expression of Early Meiosis-Specific Genes in Budding Yeast [J] . Lilach Pnueli, Iris Edry, Miriam Cohen, Molecular and Cellular Biology . 2004,第12期

机译：葡萄糖和氮气调节从组蛋白脱乙酰向乙酰化的转变，用于芽胞酵母中早期减数分裂特异性基因的表达
5. Dynamic Phosphorylation Regulates Histone Deacetylase Localization, Interactions, and Cell Cycle-dependent Functions [C] . Amanda J. Guise, Rommel A. Mathias, Todd M. Greco, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2013

机译：动态磷酸化调节组蛋白脱乙酰酶定位，相互作用和细胞周期依赖性功能
6. Identification of factors that regulate the meiosis-specific recombinase DMC1. [D] . Holzen, Teresa M. 2005

机译：鉴定调节减数分裂特异性重组酶DMC1的因素。
7. Glucose and Nitrogen Regulate the Switch from Histone Deacetylation to Acetylation for Expression of Early Meiosis-Specific Genes in Budding Yeast [O] . Lilach Pnueli, Iris Edry, Miriam Cohen, 2004

机译：葡萄糖和氮调节从组蛋白脱乙酰向乙酰化的转变用于芽酵母中早期减数分裂特异性基因的表达。
8. Glucose and Nitrogen Regulate the Switch from Histone Deacetylation to Acetylation for Expression of Early Meiosis-Specific Genes in Budding Yeast [O] . Pnueli, Lilach, Edry, Iris, Cohen, Miriam, 2004

机译：葡萄糖和氮气调节从组蛋白脱乙酰向乙酰化的转变，用于芽孢酵母中早期减数分裂特异性基因的表达

Meisetz, a novel histone tri-methyltransferase, regulates meiosis-specific epigenesis.

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