...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cell cycle >What makes centromeric cohesion resistant to separase cleavage during meiosis I but not during meiosis II?
【24h】

What makes centromeric cohesion resistant to separase cleavage during meiosis I but not during meiosis II?

机译：是什么使着丝粒的内聚力在减数分裂I期间对分离酶裂解具有抗性，而在减数分裂II期间却不抗分离酶的裂解？

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Segregation of chromosomes during meiosis I is triggered by separase cleavage of the cohesin's Rec8 subunit along chromosome arms. Centromeric cohesin is protected from separase cleavage during meiosis I by Sgo1/MEI-S332 proteins in complex with protein phosphatase 2A (PP2A). This retention of centromeric sister chromatid cohesion is essential for faithful segregation of chromatids during the second meiotic division. While Sgo1/PP2A complex is required for protecting centromeric sister chromatid cohesion during meiosis I, it is not known what renders the centromeric cohesion sensitive to separase cleavage during meiosis II. Our data suggest that the absence of Sgo1 and PP2A from meiosis II centromeres is not sufficient to render centromeric cohesion sensitive to cleavage by separase and additional factors are required to ensure the removal of centromeric cohesion during meiosis II.
机译：减数分裂I期间染色体的分离是由沿染色体臂的粘着蛋白Rec8亚基的分离酶切割触发的。与蛋白质磷酸酶2A（PP2A）结合的Sgo1 / MEI-S332蛋白质可保护着丝粒粘着蛋白在减数分裂I期间免于分离酶裂解。在第二个减数分裂分裂过程中，对着丝粒姐妹染色单体的内聚力的保持对于染色单体的忠实分离至关重要。尽管在减数分裂I期间需要Sgo1 / PP2A复合物来保护着丝粒姐妹染色单体的内聚力，但尚不清楚是什么导致着丝粒内聚力对减数分裂II期间的分离酶裂解敏感。我们的数据表明，减数分裂II着丝粒中Sgo1和PP2A的缺失不足以使着丝粒凝聚对分离酶的分裂敏感，并且还需要其他因素来确保在减数分裂II期间消除着丝粒凝聚。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号