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首页> 外文期刊>Cell cycle >Lipocalin 2: a multifaceted modulator of human cancer.
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Lipocalin 2: a multifaceted modulator of human cancer.

机译：Lipocalin 2：人类癌症的多方面调节剂。

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摘要

Lipocalin 2 (Lcn2), a member of the lipocalin family that transports small lipophilic ligands, has gained recent attention as both a potential biomarker and a modulator of human cancers. Here we describe recent findings of the functions of Lcn2 in breast cancer and the potential mechanisms that underlie its actions. Lcn2 has been shown to induce the epithelial to mesenchymal transition (EMT) in breast cancer cells and to promote breast tumor invasion. Estrogen receptor alpha may participate in the pathway that leads to Lcn2-induced EMT. Preliminary evidence also suggests that Lcn2 may be useful as a potential non-invasive urinary biomarker of breast cancer. Elevated levels of Lcn2 have also been reported in other human cancers. The potential roles of Lcn2 in epithelial tumors as well as leukemia are also reviewed and discussed here.
机译：Lipocalin 2（Lcn2）是运输小亲脂性配体的脂环蛋白家族的成员，作为一种潜在的生物标志物和人类癌症的调节剂，最近已受到关注。在这里，我们描述了Lcn2在乳腺癌中的功能及其潜在机制的最新发现。 Lcn2已显示在乳腺癌细胞中诱导上皮向间质转化（EMT）并促进乳腺肿瘤侵袭。雌激素受体α可能参与导致Lcn2诱导的EMT的途径。初步证据还表明，Lcn2可用作潜在的乳腺癌非侵入性泌尿生物标志物。在其他人类癌症中，也有Lcn2水平升高的报道。 Lcn2在上皮肿瘤以及白血病中的潜在作用也在本文中进行了综述和讨论。

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