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Alternatively spliced p53 isoforms: alternative views or alternative functions?

机译:替代剪接的p53亚型:替代视图还是替代功能?

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摘要

The multiple functions of the tumor suppressor p53 and their regulation are under intense scrutiny since nearly thirty years. Meanwhile p53 biology has reached a remarkable and ever increasing level of complexity (e.g., see Chumakov 2007). The relatively new discovery that "p53" comprises a family of different isoforms produced by alternative splicing surely did not make things easier. So far, nine splice variants of the prototypic human p53 (p53a) have been identified. Eight of them are identical in their central part, but differ from p53a and amongst themselves in their N- and C-termini.
机译:自将近三十年来,对肿瘤抑制因子p53的多重功能及其调控一直处于严格的审查之中。同时,p53生物学已经达到了惊人的且不断增加的复杂性水平(例如,参见Chumakov 2007)。相对较新的发现“ p53”包含通过选择性剪接产生的一系列不同的同工型确实没有使事情变得容易。到目前为止,已鉴定出原型人p53(p53a)的9个剪接变体。它们中的八个在中央部分相同,但与p53a不同,并且在N末端和C末端之间彼此不同。

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