Cell cycle control plays a central role in the development and homeostasis of mul-ticellular organisms. Mis-regulation of cell cycles often leads to abnormal tissue sizes and functions in development and can cause various diseases. Even though many pathways controlling the cell cycle machinery have been characterized, the signals regulating the cell cycle during development remain poorly understood. The stereotyped nuclear division pattern in the early Drosophila embryonic development has been a good model system to study how development and cell cycle are co-regulated. Drosophila embryos develop as a syncytium and undergo thirteen rounds of synchronous mitosis without cytokinesis generating about six thousand nuclei in a common cytoplasm.
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