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首页> 外文期刊>Cell cycle >Abl promotes cadherin-dependent adhesion and signaling in myoblasts.
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Abl promotes cadherin-dependent adhesion and signaling in myoblasts.

机译：Abl促进成肌细胞中钙黏着蛋白依赖性粘附和信号传导。

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Cell-cell contact promotes myogenic differentiation but the mechanisms that regulate this phenomenon are not well understood. Cdo (also known as Cdon), an Ig superfamily member, functions as a component of cell surface complexes to promote myogenic differentiation through activation of p38alpha/beta MAP kinase. We recently showed that N-cadherin ligation activated p38alpha/beta in a Cdo-dependent manner, whereas N-cadherin ligation-dependent activation of ERK MAP kinase was not affected by loss of Cdo. The non-receptor tyrosine kinase Abl associates with Cdo during myoblast differentiation and is necessary for full activition of p38alpha/beta during this process. The Abl SH3 domain binds to a PxxP motif in the Cdo intracellular domain, and both these motifs are required for their promyogenic activity. Here we show that Abl is necessary for p38alpha/beta activation initiated by N-cadherin ligation, but in contrast to Cdo, Abl is also required for N-cadherin-dependent ERK activation. Moreover, Abl is required for efficient cadherin-mediated myoblast aggregation via modulation of RhoA-ROCK signaling. Therefore, Abl regulates N-cadherin-mediated p38alpha/beta activation by multiple mechanisms, more generally through regulation of cell-cell adhesion and specifically as a component of Cdo-containing complexes. The role of Cdo as a multifunctional coreceptor with roles in several pathways is also discussed.
机译：细胞之间的接触促进了肌原性的分化，但是调节这种现象的机制尚不十分清楚。 Cdo（也称为Cdon）是Ig的超家族成员，它是细胞表面复合物的组成部分，可通过激活p38alpha /βMAP激酶来促进肌原性分化。我们最近显示，N-钙粘着蛋白连接以Cdo依赖的方式激活p38alpha / beta，而N-钙粘着蛋白依赖ERK MAP激酶的激活不受Cdo丢失的影响。非受体酪氨酸激酶Abl在成肌细胞分化过程中与Cdo缔合，并且在此过程中是p38alpha / beta完全活化所必需的。 Abl SH3结构域与Cdo细胞内结构域中的PxxP基序结合，并且这两个基序对于其早生性活动都是必需的。在这里，我们显示Abl对于由N-钙粘蛋白连接引发的p38alpha / beta激活是必需的，但与Cdo相比，Abl对于N-钙粘蛋白依赖性ERK激活也是必需的。而且，通过调节RhoA-ROCK信号转导，有效的钙黏着蛋白介导的成肌细胞聚集需要Abl。因此，Abl通过多种机制调节N-钙黏着蛋白介导的p38alpha / beta活化，更普遍地是通过调节细胞间的黏附力，特别是作为含Cdo的复合物的组分。还讨论了Cdo作为多功能共受体在多个途径中的作用。

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