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Unexpected role of nucleoporins in coordination of cell cycle progression.

机译:核孔蛋白在协调细胞周期进程中的意外作用。

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摘要

Many human cancers have irregular chromosome content, a condition known as aneuploidy. Several nuclear pore proteins (nucleoporins/Nups) that mediate transport of RNA or macromolecules into and out of the nucleus have been implicated in mitosis. These nucleoporins are involved in molecular networks that function in a variety of mitotic processes, including chromosome condensation, sister chromatid cohesion, kinetochore assembly and spindle formation. An alteration in the concentration of Nups inside cells often causes aneuploidy. In this review, we discuss this sprouting area and the possible functions of Nups during mitosis.
机译:许多人类癌症具有不规则的染色体含量,这种情况称为非整倍性。几种介导RNA或大分子进出细胞核的核孔蛋白(nuclearporins / Nups)与有丝分裂有关。这些核孔蛋白参与在各种有丝分裂过程中起作用的分子网络,包括染色体浓缩,姐妹染色单体凝聚,动粒体组装和纺锤体形成。细胞内Nups浓度的变化通常会导致非整倍性。在这篇综述中,我们讨论了这个发芽区域以及在有丝分裂期间小睡的可能功能。

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