...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cell cycle >Variation in DNA damage response pathway activity: focus on intermediate phenotype instead of genetic polymorphisms.
【24h】

Variation in DNA damage response pathway activity: focus on intermediate phenotype instead of genetic polymorphisms.

机译：DNA损伤反应途径活性的变化：关注中间表型而不是遗传多态性。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Over the past decades it has become increasingly clear that the DNA damage response (DDR) plays a crucial role in the prevention of cancer. Our DNA is extremely vulnerable to genotoxic stress. Genotoxic insults commonly arise from within as well as from without the organism. From within, genotoxic stress can be imposed by toxic byproducts of cellular metabolism, such as reactive oxygen species. From without, genotoxic stress can be imposed by numerous chemicals as well as by irradiation, such as exposure to ionizing radiation in medical practice. The estimated number of DNA lesions is as high as 10 per cell per day. To ensure genomic stability, it is critical that an appropriate DNA damage response (DDR) is mounted. The DDR is a complex signaling network and involves detection of the lesion, induction of transient cell cycle arrest to allow time for and activation of repair and the execution of a cell fate decision. Different cell fates include resumption of cell cycle progression, induction of irreversible cell cycle arrest (cellular senescence) or induction of cell death (apoptosis). Numerous factors can modulate cell fate decision, including the efficiency of DNA repair and the degree and nature of persistent lesions.
机译：在过去的几十年中，越来越明显的是DNA损伤反应（DDR）在预防癌症中起着至关重要的作用。我们的DNA极易遭受遗传毒性压力。遗传毒性侮辱通常来自有机体内部以及外部。从内部来看，遗传毒性应激可能是由细胞代谢的有毒副产物（例如活性氧）引起的。从无到有，遗传毒性应力可能由多种化学物质以及辐射（例如在医学实践中暴露于电离辐射）施加。 DNA损伤的估计数量高达每个细胞每天10个。为了确保基因组稳定性，必须安装适当的DNA损伤响应（DDR）。 DDR是一个复杂的信号网络，涉及病变的检测，瞬时细胞周期停滞的诱导，以便有时间进行修复，激活以及执行细胞命运决定。不同的细胞命运包括细胞周期进程的恢复，不可逆细胞周期阻滞的诱导（细胞衰老）或细胞死亡的诱导（细胞凋亡）。许多因素可以调节细胞命运的决定，包括DNA修复的效率以及持续性病变的程度和性质。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号