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首页> 外文期刊>Retina >Pentraxin 3 and other inflammatory factors in central retinal vein occlusion and macular edema
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Pentraxin 3 and other inflammatory factors in central retinal vein occlusion and macular edema

机译：Pentraxin 3和其他炎性因子在视网膜中央静脉阻塞和黄斑水肿中

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PURPOSE: To evaluate the association between vitreous fluid levels of inflammatory factors and macular edema in patients with central retinal vein occlusion (CRVO). METHODS: In 30 CRVO patients with macular edema and 29 controls with idiopathic macular hole, vitreous fluid samples were obtained during vitreoretinal surgery. Retinal ischemia was evaluated from capillary nonperfusion on fluorescein angiography. Macular edema was examined by optical coherence tomography. RESULTS: Vitreous fluid levels of vascular endothelial growth factor (VEGF), soluble VEGF receptor 2 (sVEGFR-2), soluble intercellular adhesion molecule 1 (sICAM-1), interleukin 6 (IL-6), monocyte chemotactic protein 1 (MCP-1), and pentraxin 3 (PTX3) were significantly higher in CRVO patients than in macular hole patients. Vitreous fluid levels of VEGF, sICAM-1, IL-6, MCP-1, and PTX3 were significantly correlated with the retinal thickness at the central fovea. There were significant correlations between the vitreous fluid level of VEGF and the levels of sICAM-1, IL-6, and MCP-1 in the CRVO patients. There was also a significant correlation between sVEGFR-2 and PTX3 but not between VEGF and PTX3. CONCLUSION: These findings suggest the importance of VEGF, its signal transduction pathways, and the cytokine network and may be useful for understanding the mechanism of macular edema in CRVO and developing new treatments.
机译：目的：评估视网膜中央静脉阻塞（CRVO）患者玻璃体液中炎症因子水平与黄斑水肿之间的关系。方法：在30例CRVO黄斑水肿患者和29例特发性黄斑裂孔对照中，在玻璃体视网膜手术中获得了玻璃体液样本。通过在荧光素血管造影上的毛细血管非灌注评估视网膜缺血。通过光学相干断层扫描检查黄斑水肿。结果：玻璃体液中的血管内皮生长因子（VEGF），可溶性VEGF受体2（sVEGFR-2），可溶性细胞间粘附分子1（sICAM-1），白介素6（IL-6），单核细胞趋化蛋白1（MCP- 1）和Pentraxin 3（PTX3）在CRVO患者中明显高于黄斑裂孔患者。 VEGF，sICAM-1，IL-6，MCP-1和PTX3的玻璃体液水平与中央凹中央的视网膜厚度显着相关。 CRVO患者的玻璃体液中VEGF水平与sICAM-1，IL-6和MCP-1水平之间存在显着相关性。 sVEGFR-2和PTX3之间也存在显着相关性，而VEGF和PTX3之间没有显着相关性。结论：这些发现提示VEGF，其信号转导途径和细胞因子网络的重要性，可能有助于了解CRVO中黄斑水肿的机制并开发新的治疗方法。

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