Tunicamycin inhibits diabetes

Shaabani N.; Honke N.; Lang P.A.; G?rg B.; Proksch P.; Gailus N.; Gotoh T.; H?ussinger D.; Lang K.S.

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Tunicamycin inhibits diabetes

机译：衣霉素抑制糖尿病

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Autoimmune diseases are characterized by a breakdown of immunologic tolerance, and this breakdown can lead to life-threatening or lifelong disorders. Moreover; drugs that are used to treat these diseases are few in number and are associated with many serious adverse effects. Methods: We used the rat insulin promoter-glycoprotein mouse model to analyze the role of tunicamycin in the process of autoimmune diabetes; the P14 mouse model to analyze the effect of tunicamycin on CD8 ~+ T cells; chop knockout mice to analyze the role of tunicamycin on an endoplasmic reticulum stress model; and fluorescence-activated cell sorting, quantitative real-time polymerase chain reaction, and histologic methods. Results: We found that a single dose of tunicamycin reduced the activation and pancreatic infiltration of CD8 ~+ T cells. This activity delayed the incidence of virus-induced diabetes and improved survival rates. Conclusion: Tunicamycin may offer therapeutic opportunities for T cell-mediated autoimmune diseases such as diabetes.

机译：自身免疫性疾病的特征是免疫耐受性下降，这种破坏可能导致威胁生命或终生疾病。此外;用于治疗这些疾病的药物数量很少，并且与许多严重的不良反应有关。方法：我们使用大鼠胰岛素启动子-糖蛋白小鼠模型分析衣霉素在自身免疫性糖尿病过程中的作用;用P14小鼠模型分析衣霉素对CD8〜+ T细胞的作用;敲除小鼠以分析衣霉素在内质网应激模型中的作用;荧光激活细胞分选，实时定量聚合酶链反应和组织学方法。结果：我们发现单剂量的衣霉素减少了CD8〜+ T细胞的活化和胰腺浸润。这种活动延迟了病毒诱发的糖尿病的发生并提高了生存率。结论：衣霉素可能为糖尿病等T细胞介导的自身免疫性疾病提供治疗机会。

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《Cellular Physiology and Biochemistry》 |2012年第4期|共8页
作者
Shaabani N.; Honke N.; Lang P.A.; G?rg B.; Proksch P.; Gailus N.; Gotoh T.; H?ussinger D.; Lang K.S.;
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正文语种 eng
中图分类细胞生理学;
关键词
Diabetes; Endoplasmic reticulum stress; Lymphocytic choriomeningitis virus; Oxidative stress; Tunicamycin;

机译：糖尿病;内质网应激;淋巴细胞性脉络膜脑膜炎病毒;氧化应激;土霉素;

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1. Tunicamycin inhibits diabetes [J] . Shaabani N., Honke N., Lang P.A., Cellular Physiology and Biochemistry . 2012,第3a4期

机译：衣霉素抑制糖尿病
2. Tunicamycin induces ER stress and inhibits tumorigenesis of head and neck cancer cells by inhibiting N-glycosylation [J] . Yang Wang, Ling Zhang, Zhiyan He, American Journal of Translational Research . 2020,第2期

机译：Tunicamycin通过抑制N-糖基化诱导ER应激并抑制头部和颈部癌细胞的肿瘤瘤
3. Dipeptidyl petidase-IV inhibitor (gemigliptin) inhibits tunicamycin-induced endoplasmic reticulum stress, apoptosis and inflammation in H9c2 cardiomyocytes [J] . Hwang Hwan-Jin, Jung Tae Woo, Ryu Ja Young, Molecular and Cellular Endocrinology . 2014,第1a2期

机译：Depteptidyl petidase-IV抑制剂（gemigliptin）抑制衣霉素诱导的H9c2心肌细胞内质网应激，凋亡和炎症
4. Discovery of Novel α-Amylase Inhibitors as Type Two Diabetes Mellitus Therapy through Fragment-Based Drug Design [C] . Muhammad Fauzi Hidayat, Eka Gunarti Ningsih, Ahmad Husein Alkaff International Conference on Science and Technology . 2020

机译：通过碎片的药物设计发现新型α-淀粉酶抑制剂作为两种糖尿病疗法
5. Facilitators and Inhibitors of Independent Self-Management of Adolescents with Type 1 Diabetes [D] . Meadows, Rita Elizabeth Jean. 2020

机译：1型糖尿病的青少年独立自我管理的促进者和抑制剂
6. Tunicamycin induces ER stress and inhibits tumorigenesis of head and neck cancer cells by inhibiting N-glycosylation [O] . Yang Wang, Ling Zhang, Zhiyan He, 2020

机译：衣霉素通过抑制N-糖基化而诱导内质网应激并抑制头颈癌细胞的肿瘤发生
7. Secretion of proteins from liver cells is suppressed by the proteinase inhibitor N-α-tosyl-L-lysyl chloromethane, but not by tunicamycin, an inhibitor of glycosylation [O] . Edwards Kaylene, Nagashima Mariko, Dryburgh Heide, 1979

机译：蛋白酶抑制剂N-α-甲苯磺酰基-L-赖氨酰氯甲烷抑制肝细胞中蛋白质的分泌，但糖基化抑制剂丁卡霉素则不能抑制这种分泌

Tunicamycin inhibits diabetes

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