...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cellular Physiology and Biochemistry >Influence of NO synthase inhibitor L-NAME on parasitemia and survival of Plasmodium berghei infected mice
【24h】

Influence of NO synthase inhibitor L-NAME on parasitemia and survival of Plasmodium berghei infected mice

机译：NO合酶抑制剂L-NAME对伯氏疟原虫感染小鼠寄生虫血症和存活的影响

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Accelerated suicidal death or eryptosis of infected erythrocytes may delay development of parasitemia in malaria. Eryptosis is inhibited by nitric oxide (NO). The present study has been performed to explore, whether inhibition of NO synthase by L-NAME modifies the course of malaria. We show here that L-NAME (>= 10 mu M) increased phosphatidylserine exposure of Plasmodium falciparum infected human erythrocytes, an effect significantly more marked than in noninfected human erythrocytes. We further show that parasitemia in Plasmodium berghei infected mice was significantly decreased (from 50% to 18% of circulating erythrocytes 20 days after infection) by addition of 1 mg/ml L-NAME to the drinking water. According to CFSE labelling L-NAME treatment accelerated the clearance of both, noninfected and infected, erythrocytes from circulating blood, but did not significantly extend the life span of infected animals. In conclusion, treatment with L-NAME shortens the life span of circulating erythrocytes and thus delays development of parasitemia during malaria.
机译：自杀死亡或感染红细胞的加速死亡可能会延迟疟疾中寄生虫病的发生。一氧化氮（NO）抑制了加密。进行本研究以探索L-NAME对NO合酶的抑制是否改变了疟疾的进程。我们在这里显示，L-NAME（> = 10μM）增加了恶性疟原虫感染的人红细胞的磷脂酰丝氨酸暴露，这种作用比未感染的人红细胞显着得多。我们进一步表明，通过向饮用水中添加1 mg / ml L-NAME，感染伯氏疟原虫的小鼠中的寄生虫血症显着降低（感染后20天从循环红细胞的50％降至18％）。根据CFSE标记的L-NAME处理，可以加速循环血液中未感染和感染的红细胞的清除，但并未显着延长被感染动物的寿命。总之，用L-NAME进行治疗可缩短循环红细胞的寿命，从而延缓疟疾期间寄生虫病的发生。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号