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首页> 外文期刊>Cell cycle >Aging, sarcopenia and store-operated calcium entry: a common link?
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Aging, sarcopenia and store-operated calcium entry: a common link?

机译：衰老，肌肉减少症和商店经营的钙进入：一个共同的环节？

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摘要

While overall bodily functions decrease with aging, the impact on some specific tissues produces life-changing consequences. For instance, skeletal muscle reduction in size and especially in function has tremendous negative implications for the individual, family and society. The aging-related loss of muscle mass and strength leads to reduced quality of life, because muscle weakness itself is a co-morbidity that can lead to other pathological conditions. For example, a weaker elderly person is more prone to fall and suffer bone fractures, losing his/ her independence and becoming anxious and depressed. Furthermore, difficulties in bone healing and long-term immobility can lead to the worsening or development of other chronic conditions. Less muscle also translates into metabolic diseases or imbalances that contribute to diabetes and cardiovascular diseases. For these reasons, sarcopenia has a very high price tag, with the world-wide related cost of sarcopenia and its consequences likely to be in the hundreds of billions of dollars.
机译：虽然整体身体功能会随着衰老而降低，但对某些特定组织的影响会改变生活。例如，骨骼肌尺寸的减小，特别是功能的减小，对个人，家庭和社会都有巨大的负面影响。与衰老相关的肌肉质量和力量的丧失导致生活质量下降，因为肌肉无力本身是一种合并症，可能导致其他病理状况。例如，一个较弱的老年人更容易跌倒并遭受骨折，失去自己的独立性，并变得焦虑和沮丧。此外，骨骼愈合困难和长期不动会导致其他慢性病恶化或发展。较少的肌肉也会转化为导致糖尿病和心血管疾病的代谢疾病或失衡。由于这些原因，肌肉减少症具有很高的价格标签，与全世界相关的肌肉减少症的成本及其后果可能在数千亿美元中。

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