• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cellular Physiology and Biochemistry >The effects of 17β-estradiol on mitochondrial biogenesis and function in breast cancer cell lines are dependent on the ERα/ERβ Ratio
【24h】

The effects of 17β-estradiol on mitochondrial biogenesis and function in breast cancer cell lines are dependent on the ERα/ERβ Ratio

机译：17β-雌二醇对乳腺癌细胞株线粒体生物发生和功能的影响取决于ERα/ERβ比

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

17β-estradiol (E2) is a risk factor for the development of breast cancer, and cause tumorigenesis in epithelial breast cells. Moreover, E2 has distinct effects on different tissues that are attributed to the presence of two estrogen receptor isoforms, ERα and ERβ. Methods: The effect of E2 on mitochondrial biogenesis and function was investigated in two breast cancer cell lines with different estrogen receptor ratios, MCF-7 (high ERα/ERβ ratio) and T47D (low ERα/ERβ ratio) cell lines treated with physiological concentrations of E2 (1 nM). Results: Mitochondria of the MCF-7 cell line showed an increase in proliferation but a decrease in functionality, while the T47D cell line, with low ERα/ERβ ratio, maintained functionality with fewer mitochondria. Conclusion: Our results suggest that ERs endowment and its subtypes relation have an effect on treatment response and could contribute new ideas about mitochondria and ERs in breast cancer, as well as new indicators to the disease progression.
机译：17β-雌二醇（E2）是乳腺癌发展的危险因素，并导致上皮性乳腺癌细胞发生肿瘤。而且，E2对不同组织具有不同的作用，这归因于两种雌激素受体同工型ERα和ERβ的存在。方法：在生理浓度处理的两种具有不同雌激素受体比的乳腺癌细胞系MCF-7（高ERα/ERβ比）和T47D（低ERα/ERβ比）细胞系中研究了E2对线粒体生物发生和功能的影响。 E2（1 nM）。结果：MCF-7细胞线粒体显示出增殖增加但功能降低，而具有低ERα/ERβ比的T47D细胞系保持了功能性，线粒体较少。结论：我们的结果表明，雌激素受体的and赋及其亚型关系对治疗反应有影响，并可能为乳腺癌的线粒体和雌激素受体提供新思路，并为疾病进展提供新的指标。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号