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首页> 外文期刊>Respiratory medicine >Environmental tobacco smoke (ETS) exposure in children with asthma-relation between lead and cadmium, and cotinine concentrations in urine.
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Environmental tobacco smoke (ETS) exposure in children with asthma-relation between lead and cadmium, and cotinine concentrations in urine.

机译：哮喘与铅和镉之间的关系以及尿液中可替宁浓度的儿童所处的环境烟草烟雾（ETS）暴露量。

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Exposure to heavy metals from environmental tobacco smoke (ETS) was investigated in 23 children with asthma (8.4+/-3.7 yr). ETS exposure was assessed by an inquiry data-based exposure index, the urinary concentration of cotinine (U-cotinine; a major nicotine metabolite) and the house dust (fine and coarse fractions) concentrations of nicotine at home. The corresponding concentrations of the heavy metals cadmium and lead in dust and urine (U-Cd; U-Pb) were determined in the same samples. There were strong associations between the ETS exposure index and U-cotinine (r(s)=0.62; P<0.002) and nicotine in house dust (r(s)=0.77; P<0.001). There was a strong positive correlation between lead and cadmium concentrations in both fine (r(s)=0.86; P<0.001) and coarse dust (r(s)=0.57; P=0.02). Although, there was a tendency for a relation between nicotine and lead concentrations in fine dust (r(s)=0.52; P=0.06), no other significant associations were found between house dust metals and nicotine concentrations. U-Cd correlated well with U-cotinine (r(s)=0.50; P=0.02). Further, U-Pb were associated with U-cotinine, however not statistically significant (r(s)=0.41; P=0.06). A probable explanation is a direct inhalation of side-stream smoke containing heavy metals and/ or an increased pulmonary uptake, due to a small airways disease in children with asthma.
机译：在23名哮喘儿童（8.4 +/- 3.7岁）中调查了环境烟草烟雾（ETS）中重金属的暴露。 ETS暴露通过基于查询数据的暴露指数，可替宁（U-烟碱;主要的尼古丁代谢产物）的尿液浓度和家里烟尘（细颗粒和粗颗粒）的浓度进行评估。在相同样品中测定了灰尘和尿液中的重金属镉和铅（U-Cd; U-Pb）的相应浓度。 ETS暴露指数与U-烟碱（r（s）= 0.62; P <0.002）和屋尘中的尼古丁之间有很强的关联（r（s）= 0.77; P <0.001）。在细粉尘（r（s）= 0.86; P <0.001）和粗粉尘（r（s）= 0.57; P = 0.02）中铅和镉的浓度之间存在很强的正相关。尽管细粉尘中的尼古丁与铅浓度之间存在关系的趋势（r（s）= 0.52; P = 0.06），但在房屋尘埃金属与尼古丁浓度之间未发现其他显着关联。 U-Cd与U-烟碱具有很好的相关性（r = 0.50; P = 0.02）。此外，U-Pb与U-烟碱相关，但无统计学意义（r（s）= 0.41; P = 0.06）。可能的解释是由于哮喘儿童的小呼吸道疾病，直接吸入了含有重金属的侧流烟雾和/或增加了肺部吸收。

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