...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Respiratory medicine >Clinical and physiological features of postinfectious chronic cough associated with H1N1 infection
【24h】

Clinical and physiological features of postinfectious chronic cough associated with H1N1 infection

机译：H1N1感染后感染后慢性咳嗽的临床和生理特征

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: Post infectious chronic cough is a disabling illness. In 2009 an influenza pandemic occurred due to a novel strain of H1N1 influenza. Prolonged symptoms such as chronic cough remaining after the infection has cleared have not been examined. This study sought to investigate the prevalence, characteristics and mechanism of chronic cough following laboratory-confirmed H1N1 2009 influenza. Methods: Out of 836 eligible patients who had been tested by PCR assay for H1N1, 136 responders participated. Nineteen underwent detailed clinical investigation of cough, and airway function using symptom questionnaires, hypertonic saline challenge, and cough monitoring. Results: Post H1N1 chronic cough was reported by 43%, and chronic cough after non-H1N1 infection was present in 36% of participants. In the participants who progressed to testing objectively measured cough frequency was 3 times greater; there was a 9-fold increase in cough reflex sensitivity and greater quality of life impairment in the participants with postinfectious chronic cough following H1N1 infection than for the participants with no cough following H1N1 infection and for the healthy controls. Conclusions: This study reports the first evaluation of chronic cough following H1N1 infection. Patients that develop chronic cough after H1N1 infection display increased cough reflex sensitivity up to 220 days after confirmed infection. There is an absence of associated risk factors and less impairment in quality of life compared to those patients normally seen in a specialist cough clinic. The associated mechanism was found to be cough reflex hypersensitivity. Trial Registration: This clinical trial has been registered with the Australian New Zealand Clinical Trials Register, ACTRN12610000540011.
机译：背景：传染性慢性咳嗽是一种致残性疾病。 2009年，由于新型H1N1流感病毒株而导致流感大流行。长期症状，如感染清除后仍残留慢性咳嗽，尚未检查。这项研究旨在调查实验室确认的2009年H1N1流感之后慢性咳嗽的患病率，特征和机制。方法：在836例接受过H1N1 PCR检测的合格患者中，有136位应答者参加了研究。 19名患者使用症状问卷，高渗盐水刺激和咳嗽监测对咳嗽和气道功能进行了详细的临床研究。结果：H1N1感染后发生慢性咳嗽的比例为43％，非H1N1感染后的慢性咳嗽发生率为36％。进行客观测试的参与者中，咳嗽频率的测量值是原来的3倍;与H1N1感染后无咳嗽的参与者和健康对照组相比，H1N1感染后感染后慢性咳嗽的参与者的咳嗽反射敏感性和生活质量受损的患者增加了9倍。结论：本研究报告了H1N1感染后对慢性咳嗽的首次评估。 H1N1感染后出现慢性咳嗽的患者在确认感染后的220天内表现出更高的咳嗽反射敏感性。与通常在专科咳嗽诊所中看到的那些患者相比，没有相关的危险因素并且生活质量的损害更少。发现相关的机制是咳嗽反射超敏反应。试验注册：该临床试验已在澳大利亚新西兰临床试验注册簿（ACTRN12610000540011）中注册。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号