OBJECTIVE: To evaluate the effects of weight change on asthma control, asthma-related quality of life, number of steroid bursts, and exacerbation of asthma symptoms in a population of adult patients with severe or difficult-to-treat asthma who participated in The Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens (TENOR) study. METHODS: We categorized 2396 TENOR patients > or = 18 years into three groups (> or = 5 lb loss, stable, > or = 5 lb gain), based on a +/-5 lb (2.27 kg) difference between baseline and 12-month follow-up weight. We used proportional odds and logistic regression models to evaluate the effect of weight change on Asthma Therapy Assessment Questionnaire (ATAQ) and Asthma Quality of Life Questionnaire (AQLQ) scores, exacerbations, and steroid bursts at the 12-month follow-up. RESULTS: Asthma patients who gained > or = 5 lb (2.27 kg) during the 12-month interval between baseline and follow-up reported poorer asthma control (adjusted odds ratio [OR]: 1.22; 95% confidence interval [CI]: 1.01-1.49; p=0.04), worse quality of life (least square means: -0.18; 95% CI: -0.30 to -0.06; p=0.003), and a greater number of steroid bursts (OR: 1.31; CI: 1.04-1.66; p=0.02) than patients who maintained their baseline weight or lost > or = 5 lb (2.27 kg). CONCLUSION: Increased weight is associated with worse asthma-related health outcomes. Strategies to prevent weight gain could help patients achieve better asthma control and improve asthma-related quality of life.
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机译：目的：评估体重变化对参加流行病学的成年重症或难治性哮喘成人患者的哮喘控制，与哮喘有关的生活质量，类固醇爆发次数和哮喘症状加重的影响和哮喘的自然史：结果和治疗方案（TENOR）研究。方法：我们根据基线与12岁之间的差异+/- 5磅（2.27千克），将2396名≥18岁的TENOR患者分为三组（>或= 5磅减轻，稳定，>或= 5磅增加）。个月的随访体重。在12个月的随访中，我们使用了比例赔率和逻辑回归模型来评估体重变化对哮喘治疗评估问卷（ATAQ）和哮喘生活质量问卷（AQLQ）评分，病情加重和类固醇爆发的影响。结果：在基线与随访之间的12个月间隔内体重增加或大于5磅（2.27千克）的哮喘患者报告哮喘控制较差（校正比值比[OR]：1.22; 95％置信区间[CI]：1.01） -1.49; p = 0.04），较差的生活质量（最小二乘法表示：-0.18; 95％CI：-0.30至-0.06; p = 0.003），以及更多的类固醇爆发（OR：1.31; CI：1.04） -1.66; p = 0.02），而不是保持基线体重或体重减轻或≥5磅（2.27千克）的患者。结论：体重增加与哮喘相关的健康状况恶化有关。预防体重增加的策略可以帮助患者更好地控制哮喘并改善与哮喘有关的生活质量。
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