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Inactivating Cdc25, mitotic style.

机译:灭活Cdc25,有丝分裂风格。

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摘要

Mitotic entry and exit require activation and inactivation of the Cdk1-cyclin B kinase complex, respectively. The Cdc25 protein phosphatase family activates Cdk1-cyclin B at the G2/M transition by removing inhibitory phosphate groups. Cdc25 family members, held inactive during interphase, are activated during mitotic progression in an amplification loop involving Cdk1-cyclin B. While Cdc25 activation at the G2/M transition is required for the timely initiation of mitosis, recent evidence suggests that the inactivation of Cdc25 in late mitosis may play a role in supporting Cdk1-cyclin B inactivation. Here, we discuss the mechanisms of Cdc25 regulation and how they pertain to both mitotic entry and exit.
机译:有丝分裂进入和退出分别需要Cdk1-cyclin B激酶复合物的激活和失活。 Cdc25蛋白磷酸酶家族通过去除抑制性磷酸基团在G2 / M过渡激活Cdk1-cyclinB。 Cdc25家族成员,在相间保持不活动状态,在涉及Cdk1-cyclin B的扩增环中,在有丝分裂过程中被激活。尽管及时启动有丝分裂需要在G2 / M转变中激活Cdc25,但最近的证据表明Cdc25的失活在有丝分裂晚期可能在支持Cdk1-cyclin B失活中起作用。在这里,我们讨论Cdc25调节的机制,以及它们如何与有丝分裂进入和退出有关。

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