The proteasome activator PA28γ is a novel component of the DNA double-strand break response network

Ben-AroyaS.

首页> 外文期刊>Cell cycle >The proteasome activator PA28γ is a novel component of the DNA double-strand break response network

【24h】

The proteasome activator PA28γ is a novel component of the DNA double-strand break response network

机译：蛋白酶体激活剂PA28γ是DNA双链断裂反应网络的新成分

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

A significant number of eukaryotic genes and regulatory pathways have evolved to ensure that cells replicate and segregate their genomes with high fidelity and at the correct time. Errors in this process result in aneu-ploidy, and the phenotypic consequences are usually profound and often underlie tumori-genesis. The current view is that most spontaneous chromosomal rearrangements result from double-strand breaks (DSBs). A single DSB is lethal if repaired improperly and may result in genetic alterations, which are the leading cause of cancer.

机译：已经进化出大量的真核基因和调节途径，以确保细胞以高保真度并在正确的时间复制和分离其基因组。该过程中的错误导致非倍性，表型的后果通常是深远的，通常是肿瘤发生的基础。当前观点是，大多数自发的染色体重排是由双链断裂（DSB）引起的。如果修复不当，单个DSB可能致命，并可能导致遗传变异，这是癌症的主要原因。

著录项

来源
《Cell cycle》 |2012年第3期|共2页
作者
Ben-AroyaS.;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类细胞生物学;
关键词

相似文献

外文文献
中文文献
专利

1. The proteasome activator PA28γ is a novel component of the DNA double-strand break response network [J] . Ben-AroyaS. Cell cycle . 2012,第3期

机译：蛋白酶体激活剂PA28γ是DNA双链断裂反应网络的新成分
2. DNA Ligase I Is an In Vivo Substrate of DNA-Dependent Protein Kinase and Is Activated by Phosphorylation in Response to DNA Double-Strand Breaks [J] . K.Ramachandra Bhat, Betty J.Benton, Radharaman Ray Biochemistry . 2006,第20期

机译：DNA连接酶I是DNA依赖性蛋白激酶的体内底物，并响应DNA双链断裂，通过磷酸化激活
3. Rapid and transient recruitment of DNMT1 to DNA double-strand breaks is mediated by its interaction with multiple components of the DNA damage response machinery. [J] . Ha K, Lee GE, Palii SS, Human Molecular Genetics . 2011,第1期

机译：DNMT1快速和短暂地募集到DNA双链断裂是通过其与DNA损伤反应机制的多个组成部分的相互作用而介导的。
4. Double-strand breaks on a genomic DNA caused by ultrasound: Evaluation by single DNA observation [C] . Kenmotmsu Takahiro, Ogawa Naoki, Kubota Rinko, International Symposium on Micro-NanoMechatronics and Human Science . 2013

机译：超声引起的基因组DNA双链断裂：单DNA观察评估
5. Studies on the response to DNA double-strand breaks: Damage-dependent phosphorylations and DNA end resection. [D] . Peterson, Shaun Eric. 2009

机译：对DNA双链断裂反应的研究：损伤依赖性磷酸化和DNA末端切除。
6. Involvement of the nuclear proteasome activator PA28γ in the cellular response to DNA double-strand breaks [O] . Adva Levy-Barda, Yaniv Lerenthal, Anthony J Davis, 2011

机译：核蛋白酶体激活剂PA28γ参与细胞对DNA双链断裂的反应
7. Involvement of the nuclear proteasome activator PA28γ in the cellular response to DNA double-strand breaks [O] . Adva Levy-Barda, Yaniv Lerenthal, Anthony J. Davis, 2011

机译：核蛋白酶体活化剂PA28γ在细胞反应中的参与DNA双链断裂
8. DNA Ligase I is an In Vivo Substrate of DNA-Dependent Protein Kinase and is Activated by Phosphorylation in Response to DNA Double-Strand Breaks [R] . Bhat, K. R. , Benton, B. J. , Ray, R. 2006

机译：DNa连接酶I是DNa依赖性蛋白激酶的体内底物，并通过磷酸化活化以响应DNa双链断裂

The proteasome activator PA28γ is a novel component of the DNA double-strand break response network

摘要

著录项

相似文献

相关主题

期刊订阅