P-TEFb as a target to reactivate latent HIV: Two Brds are now in hand

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P-TEFb as a target to reactivate latent HIV: Two Brds are now in hand

机译：P-TEFb作为重新激活潜在HIV的目标：现在有两个Brds

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P-TEFb is a protein kinase required for RNA polymerase II transcriptional elongation of most, if not all, mammalian protein-coding genes. P-TEFb is believed to be a therapeutic target for cancer, and inhibitors of P-TEFb are currently being evaluated in clinical trials. Additionally, P-TEFb has potential as a therapeutic target for HIV infection, as transcriptional elongation of the integrated virus is dependent upon the viral Tat protein's recruitment of P-TEFb to the TAR RNA element at the 5' end of nascent viral transcripts.

机译：P-TEFb是大多数（如果不是全部）哺乳动物编码基因的RNA聚合酶II转录延伸所需的蛋白激酶。据信P-TEFb是癌症的治疗靶标，目前正在临床试验中评估P-TEFb的抑制剂。另外，P-TEFb有潜力作为HIV感染的治疗靶标，因为整合病毒的转录伸长取决于病毒Tat蛋白将P-TEFb募集到新生病毒转录本5'末端的TAR RNA元件上。

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《Cell cycle》 |2013年第3期|共2页
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正文语种 eng
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1. P-TEFb as a target to reactivate latent HIV: Two Brds are now in hand [J] . RiceA.P. Cell cycle . 2013,第3期

机译：P-TEFb作为重新激活潜在HIV的目标：现在有两个Brds
2. Synergistic Reactivation of Latent HIV Expression by Ingenol-3-Angelate, PEP005, Targeted NF-kB Signaling in Combination with JQ1 Induced p-TEFb Activation [J] . Guochun Jiang, Erica A. Mendes, Philipp Kaiser, PLoS Pathogens . 2015,第7期

机译：Ingenol-3-Angelate，PEP005，靶向NF-kB信号与JQ1诱导的p-TEFb激活相结合的潜在HIV表达的协同激活
3. Synergistic Reactivation of Latent HIV Expression by Ingenol-3-Angelate, PEP005, Targeted NF-kB Signaling in Combination with JQ1 Induced p-TEFb Activation [J] . Guochun Jiang, Erica A. Mendes, Philipp Kaiser, PLoS Pathogens . 2015,第7期

机译：Ingenol-3-Angelate，PEP005，靶向NF-kB信号与JQ1诱导的p-TEFb激活相结合的潜在HIV表达的协同激活
4. Identification of post-translational modifications on HEXIM1 that regulate the activation of P-TEFb and HIV proviral reactivation [C] . Benlian Wang, Uri Mbonye, Giridharan Gokulrangan, ASMS Conference on Mass Spectrometry and Allied Topics . 2015

机译：确定调节p-TEFB和HIV透过再重新激活的exexim1后翻译后修饰的鉴定
5. Defining Molecular Pathways in the Transcriptional Reactivation of Latently Infected HIV-1 T-Cell Lines. [D] . Alvarado, Melanie Ann. 2017

机译：在潜伏感染的HIV-1 T细胞系的转录激活中定义分子途径。
6. P-TEFb as a target to reactivate latent HIV [O] . Andrew P. Rice 2013

机译：P-TEFb作为重新激活潜在HIV的目标
7. Synergistic Reactivation of Latent HIV Expression by Ingenol-3-Angelate, PEP005, Targeted NF-kB Signaling in Combination with JQ1 Induced p-TEFb Activation. [O] . Guochun Jiang, Erica A Mendes, Philipp Kaiser, 2015

机译：通过Ingenol-3-angelate，pEp005，靶向NF-kB信号传导与JQ1诱导的p-TEFb活化的协同重新激活潜伏的HIV表达。

P-TEFb as a target to reactivate latent HIV: Two Brds are now in hand

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