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首页> 外文期刊>Cell cycle >The pluripotency of hair follicle stem cells.
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The pluripotency of hair follicle stem cells.

机译：毛囊干细胞的多能性。

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The hair follicle bulge area is an abundant, easily accessible source of actively growing, pluripotent adult stem cells. Nestin, a protein marker for neural stem cells, is also expressed in follicle stem cells as well as their immediate differentiated progeny. The nestin-expressing hair follicle stem cells differentiated into neurons, glial cells, keratinocytes and smooth muscle cells in vitro. Hair-follicle stem cells were implanted into the gap region of a severed sciatic nerve. The hair follicle stem cells greatly enhanced the rate of nerve regeneration and the restoration of nerve function. The follicle stem cells transdifferentiated largely into Schwann cells which are known to support neuron regrowth. Function of the rejoined sciatic nerve was measured by contraction of the gastrocnemius muscle upon electrical stimulation. After severing the tibial nerve and subsequent transplantation of hair-follicle stem cells, the transplanted mice recovered the ability to walk normally. These results suggest that hair-follicle stem cells provide an important accessible, autologous source of adult stem cells for regenerative medicine.
机译：毛囊隆起区域是活跃生长的多能成年干细胞的丰富且容易获得的来源。巢蛋白是神经干细胞的蛋白质标记，在卵泡干细胞及其直接分化的子代中也表达。在体外，表达巢蛋白的毛囊干细胞分化为神经元，神经胶质细胞，角质形成细胞和平滑肌细胞。将毛囊干细胞植入到切断的坐骨神经的间隙区域。毛囊干细胞极大地提高了神经再生的速度和神经功能的恢复。卵泡干细胞主要分化为雪旺细胞，后者可支持神经元再生。通过电刺激腓肠肌收缩来测量再坐骨神经的功能。切断胫神经并随后移植毛囊干细胞后，移植的小鼠恢复了正常行走的能力。这些结果表明，毛囊干细胞为再生医学提供了成年干细胞的重要的可利用的自体来源。

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