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首页> 外文期刊>Cell cycle >A role for bone morphogenetic protein-4 in adipocyte development.
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A role for bone morphogenetic protein-4 in adipocyte development.

机译：骨形态发生蛋白4在脂肪细胞发育中的作用。

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Obesity is characterized by increases in the number of mature adipocytes. Nascent adipocytes arise from mesenchymal stem cells (MSCs) by a multi-step process--MSCs are recruited to the adipocyte lineage forming determined preadipocytes, these committed progenitors proliferate, undergo growth arrest, and finally differentiate into mature adipocytes. Although the genetic mechanisms that control the differentiation of preadipocytes into mature adipocytes are understood to a large extent, the earliest events in adipogenesis--especially the commitment of MSCs into preadipocytes--are largely unknown. Recently, bone morphogenetic protein-4 (BMP-4) has been implicated in the commitment of pluripotent MSCs to the adipocyte lineage by two independent lines of investigation. First, growth-arrested 10T1/2 cells do not normally respond to a hormonal cocktail that causes various growth-arrested preadipocyte cell lines to differentiate into adipocytes, but if 10T1/2 cells are first treated with BMP-4 they will respond to these hormonal inducers by undergoing terminal adipocyte differentiation. Second, a preadipocyte cell line, A33 cells, derived from 10T1/2 cells after exposing the cells to the DNA methyltransferase inhibitor 5-azacytidine was shown to express BMP-4, and this endogenous BMP-4 expression is required for acquisition of the preadipocyte phenotype of these cells. A role for the BMP-4 signaling pathway in adipogenesis is discussed.
机译：肥胖的特征在于成熟脂肪细胞的数量增加。新生的脂肪细胞通过多步过程从间充质干细胞（MSC）产生-MSC被募集到形成确定的前脂肪细胞的脂肪细胞谱系中，这些定型祖细胞增殖，生长停滞并最终分化为成熟的脂肪细胞。尽管在很大程度上了解了控制前脂肪细胞向成熟脂肪细胞分化的遗传机制，但是脂肪形成的最早事件（尤其是MSC进入前脂肪细胞的过程）仍然未知。最近，通过两个独立的研究领域，骨形态发生蛋白4（BMP-4）参与了多能MSC对脂肪细胞谱系的承诺。首先，生长停滞的10T1 / 2细胞通常不会对激素混合物产生反应，而鸡尾酒混合物会导致各种生长停滞的前脂肪细胞系分化为脂肪细胞，但是如果10T1 / 2细胞首先用BMP-4处理，它们将对这些激素产生反应通过经历终末脂肪细胞分化诱导剂。其次，显示将脂肪暴露于DNA甲基转移酶抑制剂5-氮杂胞苷后，来自10T1 / 2细胞的前脂肪细胞系A33细胞表达BMP-4，这种内源性BMP-4表达是获得前脂肪细胞所必需的这些细胞的表型。讨论了BMP-4信号通路在脂肪形成中的作用。

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