Gain-of-function c-CBL mutations associated with uniparental disomy of 11q in myeloid neoplasms.

Ogawa S; Shih LY; Otsu M; Koeffler HP

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Gain-of-function c-CBL mutations associated with uniparental disomy of 11q in myeloid neoplasms.

机译：与骨髓肿瘤中11q的单亲二体性相关的功能性c-CBL突变。

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c-CBL (CBL) encodes a multifunctional protein engaged in the regulation of intracellular signaling pathways.(1,2) It was first identified as a cellular counterpart of the viral oncogene, v-CBL, that causes murine lymphoma.(3,4) Although no genetic evidence existed suggesting its role in human carcinogenesis, the recent discovery of c-CBL mutations in myeloid cancers has unveiled a unique oncogenic mechanism mediated by gain-of-function of a mutated tumor suppressor, closely associated with allelic conversion of 11q arms.(5-9) In this review, we summarize our current knowledge about c-CBL mutations and discuss the molecular mechanisms of their gain-of-function.

机译：c-CBL（CBL）编码参与调节细胞内信号通路的多功能蛋白。（1,2）它首先被鉴定为病毒致癌基因v-CBL的细胞对应物，可引起鼠淋巴瘤。（3,4 ）尽管没有遗传证据表明其在人类致癌作用中的作用，但最近在髓样癌中发现c-CBL突变揭示了由突变的肿瘤抑制子的功能介导的独特致癌机制，与11q等位基因转化密切相关（5-9）在这篇综述中，我们总结了我们目前对c-CBL突变的认识，并讨论了其功能获得的分子机制。

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《Cell cycle》 |2010年第6期|共6页
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Ogawa S; Shih LY; Otsu M; Koeffler HP;
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正文语种 eng
中图分类细胞生物学;
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1. Gain-of-function c-CBL mutations associated with uniparental disomy of 11q in myeloid neoplasms. [J] . Ogawa S, Shih LY, Otsu M, Cell cycle . 2010,第6期

机译：与骨髓肿瘤中11q的单亲二体性相关的功能性c-CBL突变。
2. Gain-of-function c-CBL mutations associated with uniparental disomy of 11q in myeloid neoplasms. [J] . Ogawa S, Shih LY, Otsu M, Cell cycle . 2010,第6期

机译：在骨髓肿瘤中与下调11q的发单安生裂相关的功能性C-CBL突变。
3. Gain-of-function c-CBL mutations associated with uniparental disomy of 11q in myeloid neoplasms. [J] . Ogawa S, Shih LY, Otsu M, Cell cycle . 2010,第6期

机译：在骨髓肿瘤中与下调11q的发单安生裂相关的功能性C-CBL突变。
4. Action potential abnormalities due to loss- or gain-of-function mutations in KCNJ2 [C] . Wilders Ronald Computing in Cardiology Conference . 2014

机译：由于KCNJ2中功能丧失或获得功能突变而引起的动作电位异常
5. Feasibility & Discovery Using Fox System to Generate Gain-Of-Function Mutations with Hybrid Poplars [D] . Rauschendorfer, James Karl. 2017

机译：利用Fox系统生成具有杂交杨树功能增益突变的可行性和发现
6. Gain-of-function c-CBL mutations associated with uniparental disomy of 11q in myeloid neoplasms [O] . Seishi Ogawa, Masashi Sanada, Lee-Young Shih, -1

机译：与骨髓肿瘤中11Q天使发单安生物相关的功能性C-CBL突变
7. Gain-of-functionc-CBLmutations associated with uniparental disomy of 11q in myeloid neoplasms [O] . Seishi Ogawa, Masashi Sanada, Lee-Young Shih, 2010

机译：与骨髓瘤中11Q天发电直接相关的功能性 - COLMUTATION

Gain-of-function c-CBL mutations associated with uniparental disomy of 11q in myeloid neoplasms.

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