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首页> 外文期刊>Radiation and Environmental Biophysics >Boron neutron capture therapy (BNCT) for the treatment of liver metastases: biodistribution studies of boron compounds in an experimental model
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Boron neutron capture therapy (BNCT) for the treatment of liver metastases: biodistribution studies of boron compounds in an experimental model

机译：硼中子捕获疗法（BNCT）用于肝转移的治疗：实验模型中硼化合物的生物分布研究

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We previously demonstrated the therapeutic efficacy of different boron neutron capture therapy (BNCT) protocols in an experimental model of oral cancer. BNCT is based on the selective accumulation of ~(10)B carriers in a tumor followed by neutron irradiation. Within the context of exploring the potential therapeutic efficacy of BNCT for the treatment of liver metastases, the aim of the present study was to perform boron biodistribution studies in an experimental model of liver metastases in rats. Differentboron compounds and administration conditions were assayed to determine which administration protocols would potentially be therapeutically useful in in vivo BNCT studies at the RA-3 nuclear reactor. A total of 70 BDIX rats were inoculated in the liver with syngeneic colon cancer cells DHD/K12/TRb to induce the development of subcapsular tumor nodules. Fourteen days post-inoculation, the animals were used for biodistribution studies. We evaluated a total of 11 administration protocols for the boron compounds boronophenylalanine (BPA) and GB-10 (Na2~(10)B_(10)H_(10)), alone or combined at different dose levels and employing different administration routes. Tumor, normal tissue, and blood samples were processed for boron measurement by atomic emission spectroscopy. Six protocols proved potentially useful for BNCT studies in terms of absolute boron concentration in tumor and preferential uptake of boron by tumor tissue. Boron concentration values in tumor and normal tissues in the liver metastases model show it would be feasible to reach therapeutic BNCT doses in tumor without exceeding radiotolerance in normal tissue at the thermal neutron facility at RA-3.
机译：我们先前在口腔癌的实验模型中证明了不同的硼中子俘获治疗（BNCT）方案的治疗效果。 BNCT基于肿瘤中〜（10）B载体的选择性积累，然后进行中子辐照。在探索BNCT治疗肝转移的潜在疗效的背景下，本研究的目的是在大鼠肝转移的实验模型中进行硼生物分布研究。分析了不同的硼化合物和给药条件，以确定哪种给药方案在RA-3核反应堆的体内BNCT研究中可能对治疗有用。总共70只BDIX大鼠在肝脏中接种了同系结肠癌细胞DHD / K12 / TRb，以诱导荚膜下肿瘤结节的发展。接种后十四天，将动物用于生物分布研究。我们评估了硼化合物硼基苯丙氨酸（BPA）和GB-10（Na2〜（10）B_（10）H_（10））的11种给药方案，这些方案单独或以不同的剂量水平联合使用，并采用不同的给药途径。对肿瘤，正常组织和血液样品进行处理，以通过原子发射光谱法进行硼测量。就肿瘤中的绝对硼浓度和肿瘤组织优先吸收硼而言，六种方案被证明对BNCT研究可能有用。肝转移模型中肿瘤和正常组织中的硼浓度值表明，在RA-3的热中子设施在肿瘤中达到治疗BNCT剂量而不超过正常组织的放射耐受性将是可行的。

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