...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cell cycle >Telomere sister chromatid exchange in telomerase deficient murine cells.
【24h】

Telomere sister chromatid exchange in telomerase deficient murine cells.

机译：端粒酶缺陷型鼠细胞中端粒姐妹染色单体交换。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

We have recently demonstrated that several types of genomic rearrangements (i.e., telomere sister chromatid exchange (T-SCE), genomic-SCE, or end-to-end fusions) were more often detected in long-term cultured murine telomerase deficient embryonic stem (ES) cells than in freshly prepared murine splenocytes, even through they possessed similar frequencies of critically short telomeres. The high rate of genomic rearrangements in telomerase deficient ES cells, when compared to murine splenocytes, may reflect the cultured cells' gained ability to protect chromosome ends with eroded telomeres allowing them to escape "end crisis". However, the possibility that ES cells were more permissive to genomic rearrangements than other cell types or that differences in the microenvironment or genetic background of the animals might consequentially determine the rate of T-SCEs or other genomic rearrangements at critically short telomeres could not be ruled out.
机译：我们最近证明，在长期培养的鼠端粒酶缺陷型胚胎干中，更经常检测到几种类型的基因组重排（即端粒姐妹染色单体交换（T-SCE），基因组-SCE或端对端融合）（ ES）细胞比新鲜制备的鼠脾细胞中的细胞，即使它们具有相似的临界短端粒频率。与鼠脾细胞相比，端粒酶缺陷型ES细胞的基因组重排率很高，这可能反映出培养的细胞具有保护端粒的能力，端粒受到侵蚀，端粒受到侵蚀，从而使其能够逃脱“末端危机”。但是，ES细胞比其他细胞类型更容易发生基因组重排的可能性，或者动物的微环境或遗传背景的差异可能因此决定了T-SCEs的发生率或临界短端粒时其他基因组重排的可能性。出来。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号