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首页> 外文期刊>Radiation and Environmental Biophysics >Absence of DNA damage after 60-Hz electromagnetic field exposure combined with ionizing radiation, hydrogen peroxide, or c-Myc overexpression
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Absence of DNA damage after 60-Hz electromagnetic field exposure combined with ionizing radiation, hydrogen peroxide, or c-Myc overexpression

机译：暴露于60 Hz电磁场并结合电离辐射，过氧化氢或c-Myc过表达后，DNA损伤不存在

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摘要

The principal objective of/this study was to assess the DNA damage in a normal cell line system after exposure to 60 Hz of extremely low frequency magnetic field (ELF-MF) and particularly in combination with various external factors, via comet assays. NIH3T3 mouse fibroblast cells, WI-38 human lung fibroblast cells, LI32 human lung epithelial cells, and MCF10A human mammary gland epithelial cells were exposed for 4 or 16 h to a 60-Hz, 1 mT uniform magnetic field in the presence or absence of ionizing radiation (IR, 1 Gy), H2O2 (50 μM), or c-Myc oncogenic activation. The results obtained showed no significant differences between the cells exposed to ELF-MF alone and the unexposed cells. Moreover, no synergistic or additive effects were observed after 4 or 16 h of pre-exposure to 1 mT ELF-MF or simultaneous exposure to ELF-MF combined with IR, H2O2, or c-Myc activation.
机译：这项研究的主要目的是通过彗星试验评估暴露于60 Hz的极低频磁场（ELF-MF）后，特别是与各种外部因素结合后，对正常细胞系中的DNA损伤。在有或无电离辐射（IR，1 Gy），H2O2（50μM）或c-Myc致癌激活。获得的结果表明，单独暴露于ELF-MF的细胞与未暴露的细胞之间没有显着差异。此外，预暴露于1 mT ELF-MF或同时暴露于ELF-MF并结合IR，H2O2或c-Myc活化4或16小时后，未观察到协同或累加作用。

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