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首页> 外文期刊>Cellular Physiology and Biochemistry >Intestinal Expression of TFF and Related Genes During Postnatal Development in a Piglet Probiotic Trial
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Intestinal Expression of TFF and Related Genes During Postnatal Development in a Piglet Probiotic Trial

机译：仔猪益生菌试验产后发育过程中TFF及其相关基因的肠道表达

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Trefoil factor family (TFF) peptides provide protective and reparative effects by enhancing epithelial integrity and promoting mucosal restitution. TFF peptide expression is induced after mucosal damage. These processes are of central physiological relevance during the postnatal intestinal development and are strongly influenced during the weaning period. In piglets, weaning at early maturation stages frequently causes mucosal inflammation. The aim of this study was to evaluate postnatal intestinal TFF expression in a piglet probiotic trial. Low intestinal TFF2 expression was measured at early maturation stages. Weaning, however, was associated with a distinct response of increased TFF2 expression, indicating an important role in enhancing mucosal integrity. In the distal jejunum and ileum weaning could as well be associated with increased TFF3 mRNA levels. Differential TFF1 expression was not detected. Furthermore, TFF2 localization studies in different intestinal loci were performed by means of immunohistochemistry. Expression of selected genes (TGFA, EGFR, Cox-2) known to promote TFF signaling showed differential expression pattern as well, thereby providing further functional background. Furthermore, the expression patterns of EGFR observed in this study contribute to an advanced view of previous findings of EGFR regulation mainly obtained in rodents. An upregulated EGFR expression during early postnatal development suggests a local relevance to porcine intestinal maturation. However, a feed supplementation with the probiotic strain Enterococcus faecium did not influence TFF expression.
机译：三叶因子家族（TFF）肽通过增强上皮完整性和促进粘膜修复来提供保护和修复作用。在粘膜损伤后诱导TFF肽表达。这些过程在产后肠道发育过程中具有重要的生理相关性，并且在断奶期间受到强烈影响。在仔猪中，在早期成熟阶段断奶经常引起粘膜炎症。这项研究的目的是评估仔猪益生菌试验中产后肠道TFF的表达。在早期成熟阶段检测到肠TFF2表达低。但是，断奶与TFF2表达增加的明显反应有关，表明在增强粘膜完整性中起重要作用。在远端空肠和回肠中，断奶也可能与TFF3 mRNA水平升高有关。未检测到TFF1差异表达。此外，通过免疫组织化学进行了TFF2在不同肠道位点的定位研究。已知促进TFF信号传导的选定基因（TGFA，EGFR，Cox-2）的表达也显示出差异表达模式，从而提供了进一步的功能背景。此外，在这项研究中观察到的EGFR的表达模式有助于对以前主要在啮齿动物中获得的EGFR调节结果的高级了解。出生后早期发育过程中EGFR表达上调提示与猪肠道成熟有关。但是，补充益生菌粪肠球菌的饲料不会影响TFF的表达。

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