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首页> 外文期刊>Cellular Physiology and Biochemistry >Alpha - Lipoic Acid Decreases DNA Damage and Oxidative Stress Induced by Alcohol in the Developing Hippocampus and Cerebellum of Rat
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Alpha - Lipoic Acid Decreases DNA Damage and Oxidative Stress Induced by Alcohol in the Developing Hippocampus and Cerebellum of Rat

机译：α-硫辛酸减少酒精引起的大鼠海马和小脑DNA损伤和氧化应激。

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Background / aims: The present study was initiated in order to investigate the protective effects of alpha-lipoic acid upon ethanol-induced DNA damage, lipid peroxidation and protein oxidation in the developing rat hippocampus and cerebellum. Methods: Pregnant Wistar rats received ethanol with, or without lipoic acid from gestation day (GD) 7 throughout lactation. The changes in DNA damage, protein carbonyl, lipid hydroperoxide, catalase and superoxide dismutase activities were measured in the hippocampus and cerebellum of male offspring at the end of the lactation period. Results: The results indicated that DNA damage, lipid peroxidation and protein oxidation in the hippocampus and cerebellum were significantly elevated in animals that received alcohol. However, the catalase and superoxide dismutase activity results showed patterns that differed from those of DNA damage, lipid peroxidation and protein oxidation. Lipoic acid treatment significantly decreased DNA damage compared with the group that were administered alcohol alone, and restored the elevated protein carbonyl and lipid hydroperoxide levels to the levels of the control group. Conclusions: Our findings confirm that oxidative stress and DNA damage occur in the developing hippocampus and cerebellum as a result of alcohol administration, and also suggest that lipoic acid has protective effects as an antioxidant against alcohol-induced disorders in the developing hippocampus and cerebellum.
机译：背景/目的：本研究是为了研究α-硫辛酸对发育中的大鼠海马和小脑中乙醇诱导的DNA损伤，脂质过氧化和蛋白质氧化的保护作用。方法：妊娠Wistar大鼠在整个哺乳期的妊娠第（GD）7日开始接受含或不含硫辛酸的乙醇。在哺乳期结束时，测量雄性后代的海马和小脑中DNA损伤，蛋白质羰基，脂质氢过氧化物，过氧化氢酶和超氧化物歧化酶活性的变化。结果：结果表明，饮酒的动物海马和小脑的DNA损伤，脂质过氧化和蛋白质氧化显着升高。但是，过氧化氢酶和超氧化物歧化酶活性的结果显示出与DNA损伤，脂质过氧化和蛋白质氧化不同的模式。与单独给予酒精的组相比，硫辛酸处理显着降低了DNA损伤，并使升高的蛋白质羰基和脂质过氧化氢水平恢复到对照组水平。结论：我们的发现证实，饮酒可导致发育中的海马和小脑发生氧化应激和DNA损伤，并且还表明硫辛酸作为抗氧化剂可抵抗发育中的海马和小脑中的酒精引起的疾病。

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