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The relationships among dyspnoea,, health-related quality of life and psychological factors in sarcoidosis

机译：结节病的呼吸困难，与健康有关的生活质量和心理因素之间的关系

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Background and objectives: Dyspnoea is a common symptom in sarcoidosis and is not predictably related to pulmonary function or radiology. A subjective symptom of dyspnoea is likely to be influenced by patient perception and experience. The aim of this study was to determine the prevalence and nature of dyspnoea in sarcoidosis and describe the relationship of dyspnoea to psychological factors and health-related quality of life (HRQL). Methods: Fifty-six subjects (31 men, mean age 51 years) with sarcoidosis completed an HRQL measure, St George's Respiratory Questionnaire (SGRQ), Hospital Anxiety and Depression Scale (HADS) and Nijmegen questionnaire. The presence of symptoms of dyspnoea was noted and qualitative descriptors for dyspnoea were chosen at peak exercise. Resting pulmonary function was performed. Results: Sixty-four per cent of the subjects reported dyspnoea. Those with symptoms were older, had a longer duration of disease and with lower forced expiratory volume in 1 s (FEV_1) and FEVi/forced vital capacity (FVC) (all P < 0.05). Symptoms of dyspnoea were associated with worse HRQL (P < 0.005) and higher scores on the Nijmegen questionnaire (P < 0.05). Anxiety was not associated with dyspnoea and only a trend to greater depression was observed (P = 0.066). In multivariate analysis, SGRQ and Nijmegen scores predicted dyspnoea independent of demographic factors and resting pulmonary function. Conclusion: Dyspnoea is common in sarcoidosis and is associated with worse HRQL irrespective of baseline pulmonary function. Hyperventilation appears to be a factor contributing to dyspnoea and the Nijmegen questionnaire may be helpful in assessing dyspnoea and hyperventilation in sarcoidosis patients.
机译：背景与目的：呼吸困难是结节病的常见症状，与肺功能或放射学没有可预测的关系。呼吸困难的主观症状可能会受到患者感知和经验的影响。这项研究的目的是确定结节病中呼吸困难的患病率和性质，并描述呼吸困难与心理因素和与健康相关的生活质量（HRQL）的关系。方法：56名结节病患者（31名男性，平均年龄51岁）完成了HRQL测量，圣乔治呼吸问卷（SGRQ），医院焦虑抑郁量表（HADS）和奈梅亨问卷。注意到呼吸困难症状的存在，并且在运动高峰时选择了呼吸困难的定性描述。进行休息的肺功能。结果：64％的受试者报告呼吸困难。有症状的患者年龄较大，病程较长，在1 s内的呼气量较低（FEV_1），FEVi /强迫肺活量（FVC）（均P <0.05）。呼吸困难的症状与HRQL较差（P <0.005）和奈梅亨问卷中的较高分数有关（P <0.05）。焦虑与呼吸困难无关，仅观察到抑郁加剧的趋势（P = 0.066）。在多变量分析中，SGRQ和奈梅亨分值可预测呼吸困难，而与人口统计学因素和静息肺功能无关。结论：呼吸困难在结节病中很常见，并且与基线肺功能无关而与较差的HRQL相关。过度换气似乎是引起呼吸困难的因素，奈梅亨问卷调查表可能有助于评估结节病患者的呼吸困难和过度换气。

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