Efficacy and tolerability of budesonide/formoterol added to tiotropium compared with tiotropium alone in patients with severe or very severe COPD: A randomized, multicentre study in East Asia

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Efficacy and tolerability of budesonide/formoterol added to tiotropium compared with tiotropium alone in patients with severe or very severe COPD: A randomized, multicentre study in East Asia

机译：与单独使用噻托溴铵相比，在噻托溴铵中联合布地奈德/福莫特罗治疗重度或非常重度COPD的疗效和耐受性：东亚一项随机，多中心研究

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Background and objectiveTriple combination therapy with tiotropium plus budesonide/formoterol has improved lung function and reduced exacerbation risk in patients with chronic obstructive pulmonary disease (COPD) in Western countries, but no such data exist for East Asian patients. This study aimed to evaluate the efficacy and tolerability of adding budesonide/formoterol to tiotropium compared with tiotropium alone in East Asian patients with severe/very severe COPD.

机译：背景与目的噻托溴铵联合布地奈德/福莫特罗三联疗法在西方国家的慢性阻塞性肺疾病（COPD）患者中改善了肺功能并降低了加重风险，但东亚患者尚无此类数据。这项研究旨在评估在重度/非常重度COPD的东亚患者中，与单独使用噻托溴铵相比，向噻托溴铵中添加布地奈德/福莫特罗的疗效和耐受性。

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《Respirology :》 |2016年第1期|共9页
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正文语种 eng
中图分类呼吸系及胸部疾病;
关键词
budesonide; formoterol; chronic obstructive pulmonary disease; East Asia; tiotropium;

机译：布地奈德;福莫特罗;慢性阻塞性肺疾病;东亚;噻托溴铵;

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1. Efficacy and tolerability of budesonide/formoterol added to tiotropium compared with tiotropium alone in patients with severe or very severe COPD: A randomized, multicentre study in East Asia [J] . Respirology : . 2016,第1期

机译：与单独使用噻托溴铵相比，在噻托溴铵中联合布地奈德/福莫特罗治疗重度或非常重度COPD的疗效和耐受性：东亚一项随机，多中心研究
2. A CLINICAL STUDY ON SAFETY AND EFFICACY OF FORMOTEROL AND TIOTROPIUM COMBINATION COMPARED TO FORMOTEROL AND TIOTROPIUM WITH ROFLUMILAST COMBINATION IN TREATMENT OF MODERATE TO SEVERE CHRONIC OBSTRUCTIVE PULMONARY DISEASE PATIENTS [J] . Kavitha Devi M, Sarumathy S, Sarath Lal Sasidharan, Asian Journal of Pharmaceutical and Clinical Research . 2018,第3期

机译：甲酚和噻托溴铵与甲酚和噻托溴铵联用氟鲁司特合治疗中重度慢性阻塞性肺疾病的安全性和有效性的临床研究
3. A multicenter, randomized, double-blind dose-ranging study of glycopyrrolate/formoterol fumarate fixed-dose combination metered dose inhaler compared to the monocomponents and open-label tiotropium dry powder inhaler in patients with moderate-to-severe COPD [J] . Tashkin Donald P., Martinez Fernando J., Rodriguez-Roisin Roberto, Respiratory medicine . 2016,第Null期

机译：与中成重度COPD患者单组分和开放标签噻托溴铵干粉吸入器相比，格隆溴铵/富马酸福莫特罗固定剂量联合剂量吸入器的多中心，随机，双盲剂量范围研究
4. Alterations of diaphragm and rib cage morphometry in severe COPD patients by CT analysis [C] . Salito C., Luoni E., Aliverti A. Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2015

机译：严重COPD患者patients肌和肋骨笼形态的CT分析
5. Treadmill Endurance during Treatment with Tiotropium for Two Years in Patients with COPD: A Randomized Trial [D] . Cooper, Christopher Brian 2013

机译：慢性阻塞性肺病患者使用噻托铵治疗两年期间的跑步机耐力：一项随机试验
6. Original article: Efficacy and safety of once-daily QVA149 compared with the free combination of once-daily tiotropium plus twice-daily formoterol in patients with moderate-to-severe COPD (QUANTIFY): a randomised non-inferiority study [O] . Roland Buhl, Christian Gessner, Wolfgang Schuermann, -1

机译：原始文章：每日一次QVA149与每日一次噻托溴铵加每日两次福莫特罗的免费组合治疗中重度COPD（QUANTIFY）的疗效和安全性：一项随机非自卑性研究
7. Efficacy and safety of once-daily QVA149 compared with the free combination of once-daily tiotropium plus twice-daily formoterol in patients with moderate-to-severe COPD (QUANTIFY): a randomised, non-inferiority study [O] . R. Buhl, C. Gessner, W. Schuermann, 2015

机译：曾经每日QVA149的疗效和安全性与一次性日常的滴度和两次甲板蛋白质的自由组合相比，中度至严重的COPD（量化）：随机的非劣级研究

Efficacy and tolerability of budesonide/formoterol added to tiotropium compared with tiotropium alone in patients with severe or very severe COPD: A randomized, multicentre study in East Asia

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