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首页> 外文期刊>Respirology : >Diffuse alveolar haemorrhage due to 5-nitroimidazole treatment.
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Diffuse alveolar haemorrhage due to 5-nitroimidazole treatment.

机译：5-硝基咪唑治疗引起的弥漫性肺泡出血。

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摘要

Diffuse alveolar haemorrhage (DAH) is indicated by the presence of red blood cells, fibrin and haemosiderin deposits in the lung parenchyma. We present a case of DAH in a 25-year-old male following 5-nitroimidazole treatment. The first episode of haemoptysis occurred following metronidazole treatment 10 months previously. The second episode of haemoptysis occurred following ornidazole treatment 10 days before admission. During his first admission, the patients haemoglobin concentration decreased to 40 g/L. The CXR was normal, whereas high resolution CT of the lungs revealed a diffuse acinonodular pattern. Serological tests for connective tissue diseases were negative. The haemorrhagic appearance of the BAL fluid obtained during fibreoptic bronchoscopy was consistent with DAH. Microbiological analysis of the BAL fluid showed no evidence for bacterial or mycobacterial infection. Haemosiderin laden macrophages were detected in BAL fluid and lung biopsy specimens. DAH due to use of 5-nitroimidazole was diagnosed on the basis of the patient's previous history and complete recovery following treatment with corticosteroid. This is the first reported case of DAH due to use of 5-nitroimidazole. Physicians should be aware of this side-effect when prescribing this group of drugs to patients.
机译：肺实质中存在红细胞，纤维蛋白和血铁蛋白沉淀，表明弥漫性肺泡出血（DAH）。我们介绍了一名5-硝基咪唑治疗后的25岁男性中的DAH病例。甲硝唑治疗10个月前发生了首例咯血。咯血第二次发作发生在奥硝唑治疗后入院前10天。在他第一次入院期间，患者血红蛋白浓度降至40 g / L。 CXR正常，而肺部的高分辨率CT显示弥漫性的腺泡状图案。结缔组织疾病的血清学检查为阴性。纤维支气管镜检查期间获得的BAL液的出血外观与DAH一致。 BAL液的微生物学分析没有发现细菌或分枝杆菌感染的证据。在BAL液和肺活检标本中检出了含铁血黄素的巨噬细胞。根据患者的既往病史和皮质类固醇激素治疗后的完全康复，诊断出使用5-硝基咪唑引起的DAH。这是由于使用5-硝基咪唑引起的首例DAH病例。在给患者开这组药物时，医师应意识到这种副作用。

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