...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Respirology : >Clinical outcomes in sarcoidosis after cessation of infliximab treatment.
【24h】

Clinical outcomes in sarcoidosis after cessation of infliximab treatment.

机译：英夫利昔单抗治疗后结节病的临床结局。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND AND OBJECTIVE: Infliximab appears to be efficacious for the treatment of recalcitrant forms of sarcoidosis. However, there are minimal data concerning the course of sarcoidosis once infliximab is discontinued. METHODS: Clinical outcomes in patients who had received infliximab and had discontinued it for at least 2 months were analysed retrospectively. The severity of involvement of the index organ from the time of discontinuation of infliximab was compared with that at the end of the follow-up period. RESULTS: Fourteen patients with sarcoidosis who had been treated with infliximab and had discontinued this therapy were identified. Before discontinuation of infliximab, 9 of the 14 patients (64%) responded to infliximab treatment and only one (7%) deteriorated. Patients who discontinued infliximab were followed for a mean of 12 months. At the end of the follow-up period, 12 of the 14 patients (86%) had deteriorated as compared with their status at the time of discontinuation of infliximab and two (14%) had remained stable. Kaplan-Meier analysis of time to clinical deterioration showed that half the patients deteriorated within 3 months of discontinuing infliximab. Patients who had discontinued infliximab appeared to be more likely to have their dose of prednisone increased. CONCLUSION: Patients with recalcitrant sarcoidosis who receive infliximab appear likely to deteriorate after discontinuation of this medication.
机译：背景与目的：英夫利昔单抗似乎对治疗顽固性结节病有效。但是，一旦英夫利昔单抗停药，关于结节病病程的数据很少。方法：回顾性分析接受英夫利昔单抗并至少停药2个月的患者的临床结局。比较了终止英夫利昔单抗后索引器官受累的严重程度与随访期末的严重程度。结果：确定了接受英夫利昔单抗治疗并中止该治疗的14例结节病患者。在停用英夫利昔单抗之前，这14例患者中有9名（64％）对英夫利昔单抗治疗有反应，只有1名（7％）恶化。停用英夫利昔单抗的患者平均随访12个月。在随访期结束时，与终止英夫利昔单抗时的状态相比，这14例患者中有12例（86％）恶化，而2例（14％）保持稳定。 Kaplan-Meier对临床恶化时间的分析表明，一半患者在停用英夫利昔单抗后3个月内恶化。停用英夫利昔单抗的患者似乎更有可能增加泼尼松的剂量。结论：接受英夫利昔单抗治疗的顽固性结节病患者在停药后可能会恶化。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号