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Poly cystic ovary syndrome: An overview

机译：多囊卵巢综合征：概述

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摘要

Polycystic ovary syndrome (PCOS) is a heterogeneous condition that represents a continuous spectrum from asymptomatic women witr. polycystic ovaries demonstrated on ultrasound through to those with the classic features of infertility, obesity and hyperandrogenaemia. It is now generally believed to be a metabolic and endocrine condition secondary to relative insulin resistance and compensatory hyperinsu-linaemia. Hyperinsulinaemia is thought to cause abnormal ovarian androgen metabolism and altered ovarian gonadotrophin response resulting in anovulation, oligoamenorrhoea and features of hyperandrogenism. Logically, therapeutic strategies aimed at correcting the insulir resistance (weight loss and insulin sensitisers) would in theory make more sense than symptom relief. The potential increased risks ol cardiovascular disease and non-insulin-dependent diabetes mellitus would also be obviated. In practice, however, several gaps exist in ou] current knowledge of the pathophysiology of PCOS with resulting challenges in strategies that aim primarily to correct insulin resistance. This article discusses the current understanding and management of polycystic ovary syndrome. Novel future research directions are suggested.
机译：多囊卵巢综合征（PCOS）是一种异质性疾病，代表无症状女性的连续症状。多囊卵巢在超声检查中一直向不育，肥胖和高雄激素血症的经典特征证明。现在通常认为是继发于相对胰岛素抵抗和代偿性高胰岛素血症的代谢和内分泌疾病。高胰岛素血症被认为会引起卵巢雄激素代谢异常，并改变卵巢促性腺激素反应，从而导致无排卵，少尿性羊水和高雄激素血症的特征。从逻辑上讲，旨在纠正胰岛素抵抗（体重减轻和胰岛素增敏剂）的治疗策略在理论上比缓解症状更有意义。还可以避免心血管疾病和非胰岛素依赖型糖尿病的潜在风险增加。然而，实际上，在目前对PCOS病理生理学的认识中存在一些空白，这在主要旨在纠正胰岛素抵抗的策略中带来了挑战。本文讨论了当前对多囊卵巢综合征的认识和治疗。建议了新的未来研究方向。

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