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首页> 外文期刊>Resuscitation. >The effect of global hypoxia on myocardial function after successful cardiopulmonary resuscitation in a laboratory model.
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The effect of global hypoxia on myocardial function after successful cardiopulmonary resuscitation in a laboratory model.

机译：在实验室模型中，成功进行心肺复苏后整体缺氧对心肌功能的影响。

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Most laboratory studies of cardiac arrest use models of ventricular fibrillation, but in the emergency room, operating room or intensive care unit, cardiac arrest frequently results from asphyxia. We sought to investigate the effect of different durations of asystole secondary to asphyxia on myocardial function after resuscitation. In a laboratory based experimental series, anaesthetized rats received either 4 or 8 min of asphyxial cardiac arrest, and following standardized resuscitation, serial transthoracic echocardiography was performed. Severe depression of left ventricular fractional shortening occurred in both groups with partial recovery only in the 4-min arrest group, while left ventricular end-diastolic diameter was increased in the 4-min group. The pH, HCO3(-) and SBE were reduced in both groups after resuscitation, but the degree of acidosis was greater in the 8-min group. In this model, transthoracic echocardiography demonstrated both systolic and diastolic impairment following asphyxial cardiac arrest, and a clear dose-effect relationship between duration of asphyxia and degree of impairment. A shorter duration of asphyxia was associated with a lesser increase in left ventricular end-diastolic dimension, compared with more protracted asphyxia; the shorter arrest was associated with better recovery of contractile function and acidosis. Increased duration of asphyxia causes increased systolic and diastolic dysfunction. These findings may have significant implications for resuscitative therapeutics. ECHO assessment may permit specific targeting of therapy directed towards systolic or diastolic function during CPR.
机译：大多数关于心脏骤停的实验室研究都使用心室纤颤模型，但是在急诊室，手术室或重症监护室，心脏骤停经常是窒息导致的。我们试图调查复苏后窒息继发于心搏停止的不同持续时间对心肌功能的影响。在以实验室为基础的实验系列中，麻醉的大鼠接受窒息性心脏骤停的时间为4或8分钟，在标准化复苏后，进行了连续经胸超声心动图检查。两组左室分数缩短严重降低，仅在4分钟停止组中部分恢复，而在4分钟组中左心室舒张末期直径增加。复苏后，两组的pH，HCO3（-）和SBE均降低，但8分钟组的酸中毒程度更大。在该模型中，经胸超声心动图显示窒息性心脏骤停后的收缩期和舒张期损害，以及窒息持续时间和损害程度之间明显的剂量效应关系。与更长时间的窒息相比，窒息的持续时间较短与左心室舒张末期尺寸的增加较少有关。逮捕时间越短，收缩功能和酸中毒的恢复就越好。窒息持续时间增加会导致收缩和舒张功能障碍增加。这些发现可能对复苏疗法具有重要意义。 ECHO评估可允许在CPR期间针对收缩或舒张功能的治疗有针对性。

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