...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Biological trace element research >Subchronic Arsenic Exposure Through Drinking Water Alters Vascular Redox Homeostasis and Affects Physical Health in Rats
【24h】

Subchronic Arsenic Exposure Through Drinking Water Alters Vascular Redox Homeostasis and Affects Physical Health in Rats

机译：饮水对亚慢性砷的暴露会改变大鼠血管的氧化还原稳态，并影响大鼠的身体健康

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

We evaluated whether arsenic can alter vascular redox homeostasis and modulate antioxidant status, taking rat thoracic aorta as a model vascular tissue. In addition, we evaluated whether the altered vascular biochemical homeostasis could be associated with alterations in the physical indicators of toxicity development. Rats were exposed to arsenic as 25, 50, and 100 ppm of sodium arsenite through drinking water for 90 consecutive days. Body weight, food intake, and water consumption were recorded weekly. On the 91st day, rats were sacrificed; vital organs and thoracic aorta were collected. Lipid peroxidation, reactive oxygen species generation, and antioxidants were assessed in the thoracic aorta. Arsenic increased aortic lipid peroxidation and hydrogen peroxide generation while decreased reduced glutathione content in a dose-dependent manner. The activities of the enzymatic antioxidants superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase were decreased. Further, arsenic at 100 ppm decreased feed intake, water consumption, and body weight from the 11th week onward. At this concentration, arsenic increased the relative weights of the liver and kidney. The results suggest that arsenic causes dose-dependent oxidative stress, reduction in antioxidative defense systems, and body weight loss with alteration in hepato-renal organosomatic indices. Overall, subchronic arsenic exposure through drinking water causes alteration in vascular redox homeostasis and at high concentration affects physical health.
机译：我们以大鼠胸主动脉为模型血管组织，评估了砷是否可以改变血管氧化还原稳态并调节抗氧化剂状态。此外，我们评估了改变的血管生化稳态是否可能与毒性发展的物理指标改变有关。大鼠连续90天通过饮用水暴露于25、50和100 ppm的亚砷酸钠砷中。每周记录体重，食物摄入量和水消耗量。第91天，处死大鼠。收集重要器官和胸主动脉。在胸主动脉中评估脂质过氧化，活性氧的产生和抗氧化剂。砷以剂量依赖的方式增加了主动脉脂质过氧化和过氧化氢的产生，同时减少了减少的谷胱甘肽含量。酶促抗氧化剂超氧化物歧化酶，过氧化氢酶，谷胱甘肽过氧化物酶和谷胱甘肽还原酶的活性降低。此外，从第11周开始，砷含量为100 ppm时，饲料摄入量，水消耗量和体重都会减少。在此浓度下，砷增加了肝脏和肾脏的相对重量。结果表明，砷会引起剂量依赖性的氧化应激，抗氧化防御系统的减少以及体重减轻以及肝肾有机体指数的改变。总体而言，通过饮用水亚慢性砷暴露会导致血管氧化还原稳态的改变，高浓度会影响身体健康。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号