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首页> 外文期刊>Resuscitation. >Ventricular fibrillation induced by transoesophageal cardiac pacing: a new model of cardiac arrest in rats.
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Ventricular fibrillation induced by transoesophageal cardiac pacing: a new model of cardiac arrest in rats.

机译：经食道心脏起搏诱发的心室颤动：大鼠心搏停止的新模型。

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OBJECTIVE: To investigate whether transoesophageal cardiac pacing can induce ventricular fibrillation (VF) and how long the cardiac pacing has to be sustained to prevent the reversion of the VF induced. METHODS: A pacing electrode was inserted orally into the oesophagus and high-frequency ventricular pacing was performed so as to elicit VF in 25 Sprague-Dawley rats. Incidences of VF and time of cardiac pacing were observed and recorded. Four minutes after onset of VF cardiopulmonary resuscitation (CPR) was initiated. RESULTS: A short interval of high-frequency ventricular pacing caused an immediate drop of blood pressure, loss of pulse and increase of right atrial pressure in the same time frame. When the cardiac pacing was terminated, VF was elicited at least once or more than once in all of the 25 rats. However, the VF elicited by the burst stimulation could be defibrillated spontaneously. With the prolongation (120-180 s) of cardiac pacing, the incidence of defibrillation of VF decreased from 100 to0%. VF persisted in 19 of 25 animals, developed into asystole in 5 of 25 animals and converted into pulseless electrical activity in 1 of 25 animals prior to CPR. Following CPR 22 of 25 animals were resuscitated. CONCLUSIONS: Transoesophageal cardiac pacing can induce VF in rats. However, the cardiac pacing is required for at least 120-180 s to ensure that VF does not spontaneously convert. We can use the technique to establish a new and simpler rat cardiac arrest (CA) model, which may facilitate experimental investigation on CPR.
机译：目的：探讨经食道心脏起搏是否可诱发心室纤颤（VF），以及必须维持心脏起搏多长时间以防止诱发的VF逆转。方法：将起搏电极经口插入食道，进行高频心室起搏，以诱发25只Sprague-Dawley大鼠的VF。观察并记录VF发生率和心脏起搏时间。发生VF心肺复苏（CPR）后四分钟。结果：短时间的高频心室起搏导致血压在同一时间段立即下降，脉搏丢失和右心房压力升高。当心脏起搏终止时，在所有25只大鼠中至少一次或多次引发VF。但是，突发刺激引起的室颤可以自发地除颤。随着心脏起搏时间的延长（120-180 s），VF的除颤发生率从100％降至0％。 VF在25只动物中的19只中持续存在，在25只动物中有25只中的5只发展为心搏停止，并在CPR之前转变为25只动物中的1只无脉动电活动。心肺复苏后，对25只动物中的22只进行复苏。结论：经食道心脏起搏可诱发大鼠室颤。但是，至少需要120-180 s进行心脏起搏，以确保VF不会自发转换。我们可以使用该技术建立新的和更简单的大鼠心脏骤停（CA）模型，这可能有助于进行心肺复苏的实验研究。

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