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Correlations between climate factors and incidence-a contributor to RSV seasonality

机译:气候因素与发病率之间的关系-造成RSV季节变化的原因

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Respiratory syncytial virus is the most common respiratory virus infection in early childhood, causing a wide range of illness from mild colds to life-threatening croup, bronchiolitis and pneumonia that may require intensive care. Exactly which parameters contribute to the seasonality of RSV (and other respiratory viruses, such as influenza) and their comparative significance are the subject of ongoing intensive debate. This review article summarises the specific contributions and correlations between the incidence of RSV and various climate parameters. This systematic review of the literature specifically focuses on these climate associations and have been stratified by study site latitudes: tropical (0-23.5 degrees N or S), subtropical (23.5-40 degrees N or S) and temperate latitudes (>40 degrees N or S). Correlations between RSV incidence and temperature and relative humidity are particularly variable and inconsistent amongst the tropical regions. In subtropical and temperate regions, RSV incidence is more consistently positively correlated with lower temperatures and higher relative humidity. Although there is some variation with the diagnostic methods used in these studies, most used immunofluorescent viral antigen testing to diagnose RSV infection. Statistically, most studies used some form of regression analysis, which assumes no dependence between data taken at different time points. A few used the autoregressive integrated moving average approach, which may be more realistic for an infectious agent as the total number of cases usually evolves in a time-dependent manner during a typical seasonal epidemic. Copyright (c) 2013 John Wiley & Sons, Ltd.
机译:呼吸道合胞病毒是儿童早期最常见的呼吸道病毒感染,可引起多种疾病,从轻度感冒到危及生命的人群,细支气管炎和肺炎,可能需要重症监护。到底哪些参数会影响RSV(和其他呼吸道病毒,例如流感)的季节性以及它们的相对重要性,这是不断进行激烈辩论的主题。这篇综述文章总结了RSV发生率与各种气候参数之间的特定贡献和相关性。本文对文献的系统综述着重于这些气候关联,并按研究地点纬度进行了分层:热带(北纬2至23.5度),亚热带(北纬23.5至40度)和温带纬度(北纬40度以上)。或S)。在热带地区中,RSV发病率与温度和相对湿度之间的相关性尤其可变且不一致。在亚热带和温带地区,RSV的发生率与较低的温度和较高的相对湿度呈正相关。尽管这些研究中使用的诊断方法有所不同,但大多数使用免疫荧光病毒抗原检测来诊断RSV感染。从统计学上讲,大多数研究使用某种形式的回归分析,即假设在不同时间点获取的数据之间没有依赖性。少数人使用了自回归综合移动平均法,这对于传染源可能更现实,因为在典型的季节性流行期间,病例总数通常以时间依赖的方式演变。版权所有(c)2013 John Wiley&Sons,Ltd.

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