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首页> 外文期刊>Biological trace element research >Protective effect of betaine on changes in the levels of membrane-bound ATPase activity and mineral status in experimentally induced myocardial infarction in Wistar rats.
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Protective effect of betaine on changes in the levels of membrane-bound ATPase activity and mineral status in experimentally induced myocardial infarction in Wistar rats.

机译:甜菜碱对Wistar大鼠实验性心肌梗死对膜结合ATPase活性水平和矿物质状态变化的保护作用。

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Cardiovascular diseases are emerging as a major public health problem in most parts of the world even in developing countries still afflicted by infectious diseases, undernutrition, and other illnesses related to poverty. In the present study, we investigated the protective effect of betaine, a potent lipotropic molecule, on changes in the levels of membrane-bound ATPase activities, lipid peroxidation, sulfhydryl activities, and mineral status in isoprenaline-induced myocardial infarction in Wistar rats, an animal model of myocardial infarction in man. Oral administration of betaine (250 mg/kg body weight/day for a period of 30 days) significantly (p < 0.05) reduced the isoprenaline-induced abnormalities noted in the levels of sodium, potassium, and calcium in plasma and heart tissue. Pretreatment with betaine significantly attenuated isoprenaline-induced membrane-bound ATPase depletion in the heart tissue and preserved the myocardial membrane-bound ATPase activities at levels comparable to that of control rats. Oral administration of betaine significantly attenuated the isoprenaline-altered sulfhydryl groups in the heart tissue and preserved the myocardial sulfhydryl activities at levels comparable to that of control rats. It also significantly counteracted the isoprenaline-mediated lipid peroxidation and maintained the level at near normal. In the results of the present study, betaine administration significantly prevented the isoprenaline-induced alterations in the activities of membrane-bound ATPases, lipid peroxides, myocardial sulfhydryl levels, and maintained the mineral status at near normal.
机译:心血管疾病在世界上大部分地区都正在成为主要的公共卫生问题,即使在仍受传染病,营养不良以及其他与贫困有关的疾病困扰的发展中国家中,心血管疾病也是如此。在本研究中,我们研究了甜菜碱(一种强力亲脂分子)对Wistar大鼠(异戊二烯诱导的心肌梗死)中膜结合ATPase活性,脂质过氧化,巯基活性和矿物质状态变化的保护作用。人心肌梗死的动物模型。口服甜菜碱(250 mg / kg体重/天,持续30天)显着(p <0.05)减少了异丙肾上腺素引起的血浆和心脏组织中钠,钾和钙水平的异常。用甜菜碱预处理可显着减轻心脏组织中异丙肾上腺素诱导的膜结合ATPase的消耗,并以与对照组大鼠相当的水平保留心肌膜结合的ATPase活性。甜菜碱的口服给药显着减弱了心脏组织中异戊二烯改变的巯基基团,并以与对照组大鼠相当的水平保留了心肌巯基活性。它还显着抵消了异丙肾上腺素介导的脂质过氧化作用,并将其水平维持在接近正常水平。在本研究的结果中,甜菜碱的施用显着阻止了异丙肾上腺素引起的膜结合ATPase,脂质过氧化物,心肌巯基水平的改变,并使矿物质状态保持在接近正常的水平。

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