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Decreasing nasal mucus Ca++ improves hyposmia.

机译:减少鼻粘液Ca ++可改善低渗症。

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It is well documented that cytoplasmic Ca++ regulates sensitivity to cyclic adenosine monophosphate (cAMP). There is also evidence that Ca++ in the mucus may also modulate sensitivity to cAMP in vivo. Assuming that mucosal Ca++ could significantly change the excitability of the receptor neurons, we examined the alterations in the olfactory sensitivity by creating small changes in mucosal Ca++. Thirty one patients complaining of olfactory loss were examined and their olfactory acuity was measured before and after the administration of a sodium citrate buffer solution in the nasal cleft. Thirty patients (96.8%) improved their scores in less than an hour period of time. Furthermore, 23 of them (74.2%) realized an improvement in their own sense of smell.
机译:已有文献证明,胞质Ca ++调节对环磷酸腺苷(cAMP)的敏感性。也有证据表明,粘液中的Ca ++还可调节体内对cAMP的敏感性。假设粘膜Ca ++可以显着改变受体神经元的兴奋性,我们通过在粘膜Ca ++中创建小的变化来检查嗅觉敏感性的变化。检查了31名抱怨嗅觉丧失的患者,并在鼻裂中施用柠檬酸钠缓冲溶液之前和之后测量了他们的嗅觉敏锐度。 30名患者(96.8%)在不到一个小时的时间内提高了评分。此外,其中有23名(74.2%)意识到自己的嗅觉得到了改善。

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