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The influence of air current on goblet cell density in the mucosa of the normal uncinate process in the nasal cavity.

机译:气流对正常人鼻腔粘膜突过程黏膜中杯状细胞密度的影响。

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AIM: To determine the density of goblet cells in the mucosa at the medial site of the uncinate process in the nasal cavity where the air current is high and compare with the goblet cell density on the protected lateral site of the uncinate process, thus establishing the function of the uncinate process in protecting the integrity of epithelium, in the meatus medius, from the distress caused by continuous airflow. Determining this function could have clinical implications, as patients routinely undergo removal of the uncinate process during endoscopic sinus surgery. MATERIAL AND METHODS: The material comprised pieces of mucosa of 11 uncinate processes from the nasal cavity of 11 autopsies. The material was stained with PAS-Alcian blue after which the goblet cells were counted using a whole-mount method. Counting was done by only 1 of the authors and was not blinded. RESULTS: The density of goblet cells was significantly higher on the lateral site than on the medial site of the uncinate process. Furthermore, goblet cell density was found to be higher on the superior part of the uncinate process, than on the inferior part. CONCLUSION: The results seem to indicate that air current has consequential impact on the normal differentiation patterns of the epithelium in the nose. The significantly higher goblet cell density on the unexposed lateral site of the uncinate process suggests that at this site the sinus outlets are protected from air current trauma.
机译:目的:确定气流高的鼻腔中未融合过程中位点粘膜中杯状细胞的密度,并与未融合过程受保护的外侧位点中的杯状细胞密度进行比较,从而确定融合过程在保护中耳上皮的完整性免受连续气流造成的困扰方面的功能。确定该功能可能具有临床意义,因为患者在内窥镜鼻窦手术期间会例行进行消除癌变的过程。材料与方法:该材料由11例尸检的鼻腔中的11例未融合过程的粘膜组成。用PAS-阿尔辛蓝对材料染色,然后使用整装法对杯状细胞进行计数。计数仅由1位作者完成,并且不致盲。结果:杯状细胞的密度在外侧部位比在未融合过程的内侧部位明显更高。此外,发现杯状细胞的密度在未融合过程的上部分高于下部分。结论:结果似乎表明气流对鼻子上皮的正常分化方式有相应的影响。在未融合过程的未暴露侧面部位,杯状细胞的密度显着较高,这表明在该部位,窦出口受到了气流的保护。

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