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首页> 外文期刊>Cellular Physiology and Biochemistry >Protective effect of melatonin on antioxidative system in experimental ischemia-reperfusion of rat small intestine
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Protective effect of melatonin on antioxidative system in experimental ischemia-reperfusion of rat small intestine

机译：褪黑素对实验性小肠缺血再灌注大鼠抗氧化系统的保护作用

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Aims: Effect of exogenously administered melatonin (N-acetyl 5-methoxytryptamine) on antioxidant systems in experimental Ischemia-Reperfusion (I-R) of rat gastrointestinal system (GIS) was examined. Methods: A total of 40 rats were divided into 4 groups: Group 1 (Sham), Group 2 (I-R), Group 3 (I-R +10 mg/ kg melatonin) and Group 4 (I-R + 20 mg/kg melatonin). Activity levels of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) were determined in small intestines. Results, There was a significant (p<0.05) reduction in GSH-Px levels in Group 2 (64.16+/-7.02 U/mg protein) compared to Group 1 (80.15+/-9.32 U/mg protein). We observed a meaningful increase in GSH-Px levels in melatonin applied groups (Group 3. 75.94+/-9.83 U/mg protein, Group 4, 78.55+/-9.11 U/mg protein) compared to Group 2, Correspondingly, SOD activity levels were significantly reduced (p<0.001) in Group 2 (24.14+/-4.35 U/mg protein) compared to controls (52.91+/-6.13 U/mg protein). A stronger effect (p<0.001) of melatonin was observed on SOD levels compared to GSH-Px levels in both doses (Group 3. 38.96+/-6.39 U/mg protein, Group 4. 43.07+/-7.76 U/mg protein). Levels of selenium were reduced significantly in Group 2 (1.11+/-0.31 g/g tissue) compared to Group 1 (2.01+/-0.19 mug/g tissue). Melatonin application in Group 3 (1.13+/-0.28 mug/g tissue) and Group 4 (1.89+/-0.48 mug/g tissue) caused an increase in selenium levels. There was a strong correlation between increases in selenium and GSH-Px levels in Group 4 (0,0.651 p<0.01). Conclusions: Melatonin seems to exert its antioxidant effect in GIS tract by stimulating SOD and GSH-Px. Selenium also seems to have an antioxidant contribution on protecting rat gastrointestinal tract I-R injury. Copyright (C) 2000 S. Karger AG, Basel. [References: 30]
机译：目的：研究了外源性褪黑素（N-乙酰基5-甲氧基色胺）对大鼠胃肠系统（GIS）缺血-再灌注（I-R）中抗氧化系统的影响。方法：将40只大鼠分为4组：第1组（假手术），第2组（I-R），第3组（I-R +10 mg / kg褪黑激素）和第4组（I-R + 20 mg / kg褪黑激素）。测定小肠中超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GSH-Px）的活性水平。结果，与组1（80.15 +/- 9.32 U / mg蛋白质）相比，组2（64.16 +/- 7.02 U / mg蛋白质）的GSH-Px水平显着降低（p <0.05）。我们观察到与第2组相比，褪黑激素应用组（第3组：75.94 +/- 9.83 U / mg蛋白，第4组，78.55 +/- 9.11 U / mg蛋白）中的GSH-Px水平显着增加。相应地，SOD活性与对照组（52.91 +/- 6.13 U / mg蛋白质）相比，第2组（24.14 +/- 4.35 U / mg蛋白质）的血脂水平显着降低（p <0.001）。与两种剂量的GSH-Px水平相比，均观察到褪黑激素对SOD水平的增强作用（p <0.001）（第3组。38.96+/- 6.39 U / mg蛋白，第4组。43.07+/- 7.76 U / mg蛋白）。与组1（2.01 +/- 0.19个杯子/ g组织）相比，组2（1.11 +/-0.31μg/ g组织）中硒的水平显着降低。第3组（1.13 +/- 0.28马克杯/克组织）和第4组（1.89 +/- 0.48马克杯/克组织）褪黑素的使用导致硒水平升高。第4组的硒水平与GSH-Px水平之间存在很强的相关性（0,0.651 p <0.01）。结论：褪黑激素似乎通过刺激SOD和GSH-Px发挥其抗氧化作用。硒似乎也对保护大鼠胃肠道I-R损伤具有抗氧化剂作用。版权所有（C）2000 S.Karger AG，巴塞尔。 [参考：30]

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