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首页> 外文期刊>Rhinology >Trigeminal event-related potentials in patients with olfactory dysfunction.
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Trigeminal event-related potentials in patients with olfactory dysfunction.

机译：嗅觉功能障碍患者的三叉事件相关电位。

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OBJECTIVE: There are mutual interactions between the olfactory and trigeminal systems. The purpose of this study was (1) to assess trigeminal sensitivity using chemosensory event-related potentials (CSERPs) in patients with olfactory dysfunction and (2) to evaluate whether trigeminal ERPs were different with regard to the presence or absence of olfactory ERPs. MATERIALS AND METHODS: Prospective study of 60 patients who presented with olfactory dysfunction (postinfectious olfactory loss: n = 19, posttraumatic olfactory loss: n = 28, and olfactory loss due to idiopathic, or toxic causes: n = 13). All patients were extensively evaluated with an orthonasal olfactory test based on the "Sniffin' Sticks". In addition, chemosensory ERPs were recorded in response to olfactory and trigeminal stimulation. RESULTS: Olfactory/trigeminal ERPs were recorded in 25/60 patients, respectively. Patients with no detectable olfactory ERPs, considered as severely affected, demonstrated an altered trigeminal sensitivity as indicated by an increase in P2 latencies and a decrease in both, P2 and N1-P2 amplitudes compared to patients with detectable olfactory ERPs. A regression analysis showed a negative relation between P2 latencies and the "Sniffin' Sticks"score (r = -0.46, p < 0.001). CONCLUSIONS: Patients with severe olfactory dysfunction demonstrated decreased trigeminal sensitivity as indicated by electrophysiological measures. This study supports the idea of interactions between the chemical senses. Whether altered responses to trigeminal stimulation may be used as a prognostic measure related to recovery from olfactory loss remains to be demonstrated.
机译：目的：嗅觉和三叉神经系统之间存在相互作用。这项研究的目的是（1）使用化学感觉事件相关电位（CSERP）评估嗅觉功能障碍患者的三叉神经敏感性，以及（2）评估三叉神经ERP在嗅觉ERP是否存在方面是否有所不同。材料与方法：前瞻性研究了60例嗅觉功能障碍患者（感染后嗅觉丧失：n = 19，创伤后嗅觉丧失：n = 28，以及因特发性或中毒原因引起的嗅觉丧失：n = 13）。根据“嗅探棒”对所有患者进行了一次嗅觉测试。此外，化学嗅觉ERPs记录响应嗅觉和三叉神经刺激。结果：分别在25/60例患者中记录了嗅觉/三叉神经ERP。没有嗅觉ERP的患者被认为受到了严重的影响，与具有嗅觉ERP的患者相比，三叉神经敏感性改变，P2潜伏期增加，P2和N1-P2幅度均降低。回归分析显示P2潜伏期与“嗅探棒”得分之间呈负相关（r = -0.46，p <0.001）。结论：严重的嗅觉障碍患者表现出三叉神经敏感性降低，如电生理指标所表明。这项研究支持化学感官之间相互作用的想法。对三叉神经刺激反应的改变是否可以用作与从嗅觉丧失中恢复有关的预后指标尚待证实。

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