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首页> 外文期刊>Rheumatic diseases clinics of North America >Genetic and environmental risk factors for idiopathic inflammatory myopathies.
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Genetic and environmental risk factors for idiopathic inflammatory myopathies.

机译：特发性炎症性肌病的遗传和环境危险因素。

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摘要

Although the studies discussed are beginning to reveal a number of genetic and possible environmental risk factors for myositis, further investigations are needed to fully understand and classify these syndromes. The difficulties in this process include small numbers of subjects with varying disease phenotypes available for study, polygenic risk factors for which it remains unclear which are primary and which are secondary or linked genes, and the lack of validated environmental exposure assessment tools. New technologies and international collaborative approaches, however, may overcome some of these difficulties and allow us to identify genetic and environmental risk factors, as well as the critical gene-environment interactions in the IIM and its subgroups. Nonetheless, our understanding of these diseases is still in the early stages. Although we have learned a great deal about these disorders through detailed investigations over the last several decades, we have even further to go to understand the environmental triggers and genetic susceptibilities for the myositis syndromes.
机译：尽管讨论的研究开始揭示肌炎的许多遗传因素和可能的环境危险因素，但仍需要进一步研究以充分理解和分类这些综合征。该过程中的困难包括少数可用于研究的具有不同疾病表型的受试者，尚不清楚哪些是主要基因，哪些是继发基因或连锁基因的多基因危险因素，以及缺乏经过验证的环境暴露评估工具。但是，新技术和国际合作方法可以克服其中的一些困难，使我们能够确定遗传和环境危险因素，以及IIM及其亚组中关键的基因-环境相互作用。尽管如此，我们对这些疾病的了解仍处于早期阶段。尽管在过去的几十年中我们通过详细的调查了解了很多有关这些疾病的知识，但我们还要进一步了解肌炎综合征的环境触发因素和遗传易感性。

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