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首页> 外文期刊>Romanian journal of internal medicine >The Oxidative Stress in the Development of Diabetes Chronic Complications in the Elderly
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The Oxidative Stress in the Development of Diabetes Chronic Complications in the Elderly

机译：老年人糖尿病慢性并发症发展中的氧化应激

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The diabetes mellitus occurs as an important disease at elderly people, to whom the micro- and macrovascular complications represent a major cause of morbidity and mortality. Experimental researches of the last years proved that the oxidative stress may be the common mechanisms that intervenes in the occurrence of the diabetes complications as well as in the aging process and is responsable for the increased prevalence of chronic complications at elderly diabetics. Starting from this information, we performed a comparative study where we followed the intensity of the oxidative stress at elderly diabetics as compared to adult diabetics and non-diabetic elderly people. At the same time, we have followed the involvement of oxidative stress in the occurrence of diabetic microangiopathy and aterosclerosis.155 patients from the 4~(th) Medical Clinic were studied during 2000-2003. These patients were divided into three lots: lot 1: elderly diabetics, lot 2: adult diabetics, lot 3: elderly non-diabetics. At these patients we have followed comparatively the intensity of the oxidant status by determining the plasmatic malondialdehide (MDA) and the anti-oxidant status by determining the plasmatic ceruloplasmin, as well as the correlations of these two parameters with the chronic complications of diabetes.At elderly diabetics there is an increased oxidative stress underlined by an increased plasmatic level of MDA and ceruloplasmin as compared to the adult diabetics and non-diabetic elderly people and this increased oxidative stress is involved in the development of the chronic complications at this patients. In case of elderly diabetics, the age and the illness may induce the formation of oxygen-derived free radicals with synergic effect in injuring tissues and organs.
机译：糖尿病是老年人的重要疾病，其微血管和大血管并发症是发病和死亡的主要原因。近年来的实验研究证明，氧化应激可能是干预糖尿病并发症发生以及衰老过程的常见机制，并且是老年人糖尿病慢性并发症患病率上升的原因。从这些信息出发，我们进行了一项比较研究，我们追踪了老年糖尿病患者与成人糖尿病患者和非糖尿病老年人相比的氧化应激强度。同时，我们还跟踪了氧化应激与糖尿病微血管病和动脉硬化的发生有关。2000-2003年期间，对第4诊所的155名患者进行了研究。这些患者分为三批：第一批：老年糖尿病患者;第二批：成人糖尿病患者;第三批：老年非糖尿病患者。在这些患者中，我们通过确定血浆丙二醛（MDA）来跟踪氧化剂状态的强度，通过确定血浆铜蓝蛋白来跟踪抗氧化剂的状态，以及这两个参数与糖尿病慢性并发症的相关性。与成年糖尿病患者和非糖尿病老年人相比，老年糖尿病患者的氧化应激增加，其血浆丙二醛和铜蓝蛋白水平升高，突显出这种氧化应激与该患者慢性并发症的发展有关。在老年糖尿病患者中，年龄和疾病可能诱导氧衍生自由基的形成，并在伤害组织和器官中起协同作用。

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