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首页> 外文期刊>Rheumatology >Central neural mechanisms of interindividual difference in discomfort during sensorimotor incongruence in healthy volunteers: An experimental study
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Central neural mechanisms of interindividual difference in discomfort during sensorimotor incongruence in healthy volunteers: An experimental study

机译：健康志愿者感觉运动不一致时个体间不适差异的中枢神经机制：一项实验研究

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Objectives. It has been reported that disturbance in sensory and motor function may induce sensorimotor incongruence and produce pain, discomfort and other sensations in healthy volunteers. One study suggested that sensorimotor incongruent information to healthy subjects results in increased neuronal activity in the posterior parietal cortex (PPC) and dorsolateral prefrontal cortex; however, this study did not take into consideration the discomfort induced by sensorimotor incongruence. The present study attempted to characterize intracortical electrical activities for sensorimotor incongruence in the frequency domain. In our study, electroencephalogram (EEG) cortical sources were compared between sensorimotor congruence and sensorimotor incongruence. In addition, high and no discomfort subgroups were compared during sensorimotor incongruence. Methods. Eighteen healthy female subjects participated in this study. Subjects were then asked to flex/extend both arms in a congruent/incongruent manner while viewing a whiteboard/mirror. EEG was performed to determine the cortical activation during sensorimotor congruence and incongruence. Results. Alpha band activity in the right posterior parietal cortex during sensorimotor incongruence was significantly lower than that of sensorimotor congruence. The source activities induced in the anterior cingulate cortex (ACC) beta band activity and the posterior cingulate cortex (PCC) alpha band activity significantly decreased in the high-discomfort vs the no-discomfort subgroup. Conclusion. The present findings suggest that the ACC and PCC are more activated in the high-discomfort subgroup than in the no-discomfort subgroup during sensorimotor incongruence. This method may evaluate the effectiveness of new medication therapy and/or rehabilitation by assessing the difference in the neuronal activity of chronic patients before and after treatment.
机译：目标。据报道，在健康志愿者中，感觉和运动功能障碍可能引起感觉运动不一致，并产生疼痛，不适和其他感觉。一项研究表明，健康受试者的感觉运动信息不一致会导致顶叶后皮质（PPC）和背外侧前额叶皮质的神经元活动增加;然而，这项研究没有考虑到感觉运动不一致所引起的不适。本研究试图表征在频域中感觉运动不一致的皮质内电活动。在我们的研究中，比较了感觉运动一致性和感觉运动不一致的脑电图（EEG）皮质来源。另外，在感觉运动不协调期间比较了高和没有不适的亚组。方法。十八名健康女性受试者参加了这项研究。然后要求受试者在查看白板/镜子时以一致/不一致的方式弯曲/伸展双臂。进行脑电图以确定感觉运动的全同和不一致期间的皮质激活。结果。感觉运动不一致时右顶壁皮质的α带活动明显低于感觉运动一致。高不适组与无不适组相比，前扣带回皮层（ACC）β带活动和后扣带回皮层（PCC）α带活动诱导的源活性显着降低。结论。目前的发现表明，在感觉运动不一致时，高不适亚组的ACC和PCC活化程度高于无不适亚组。该方法可以通过评估慢性患者治疗前后神经元活动的差异来评估新药物治疗和/或康复的有效性。

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