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首页> 外文期刊>RSC Advances >L-Proline mediated synthesis of quinoxalines; evaluation of cytotoxic and antimicrobial activity
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L-Proline mediated synthesis of quinoxalines; evaluation of cytotoxic and antimicrobial activity

机译：L-脯氨酸介导的喹喔啉合成;评估细胞毒性和抗菌活性

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摘要

A simple, greener and highly efficient method for the synthesis of functionalized quinoxalines has been developed employing L-proline as a catalyst in water. To the best of our knowledge this transformation is achieved for the first time using an organic catalyst. A small library of quinoxaline-sulphonamide conjugates have been synthesized using this protocol. The newly synthesized conjugates have been tested for their cytotoxicity and antimicrobial activity against several bacterial strains including one fungal strain. The majority of the compounds have exhibited significant cytotoxicity as well as antimicrobial activity. Compounds 5a, 5b and 5d were found to be promising with respect to both cytotoxicity and antimicrobial activity.
机译：已经开发了一种简单，绿色且高效的方法，用于合成官能化的喹喔啉，使用L-脯氨酸作为催化剂在水中。据我们所知，这种转化是首次使用有机催化剂实现的。使用该方案已合成了一个小的喹喔啉-磺酰胺共轭物库。已经测试了新合成的缀合物对几种细菌菌株（包括一种真菌菌株）的细胞毒性和抗微生物活性。大多数化合物已表现出明显的细胞毒性以及抗微生物活性。就细胞毒性和抗微生物活性而言，发现化合物5a，5b和5d是有希望的。

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