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首页> 外文期刊>Rhinology >Nasal lavage CCL24 levels correlate with eosinophils trafficking and symptoms in chronic sino-nasal eosinophilic inflammation.
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Nasal lavage CCL24 levels correlate with eosinophils trafficking and symptoms in chronic sino-nasal eosinophilic inflammation.

机译：鼻灌洗液CCL24水平与嗜酸性粒细胞运输和慢性鼻-鼻嗜酸性粒细胞炎症的症状相关。

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摘要

OBJECTIVES: The aim of our study was to measure CCL24 (eotaxin-2) levels in nasal lavage fluid of patients with different forms of sinonasal chronic eosinophilic inflammation to verify the relationship with nasal hypereosinophilia and symptoms. METHODS: Patients with nasal hypereosinophilia were randomly recruited and grouped in persistent allergic rhinitis, non-allergic rhinitis with eosinophilia syndrome (NARES) and chronic rhinosinusitis with polyps. Non rhinitic volunteers were recruited as controls. CCL24 concentration was measured by `Quantikine Human CCL24 Immunoassay`. Differential cell counts were performed by microscopic cytological examination of nasal tissue scraped by inferior turbinate. RESULTS: CCL24 levels measured in patient groups were significantly higher compared to control group with the highest levels in NARES patients. Eotaxin- 2 levels were significantly correlated to severity of symptoms and to the percentage of eosinophils in nasal tissue. CONCLUSIONS: We revealed high levels of CCL24 in all patient groups showing a significant correlation with the degree of eosinophilia and clinical symptoms. A prolonged accumulation of CCL24 inside the nasal mucosa may sustain the process of unspecific self-perpetuating eosinophil recruitment pathognomonic of these patients.
机译：目的：本研究的目的是测量患有不同形式的鼻窦慢性嗜酸性粒细胞炎症患者鼻灌洗液中的CCL24（eotaxin-2）水平，以验证其与鼻嗜酸性粒细胞增多和症状的关系。方法：随机招募鼻高嗜酸性粒细胞增多症患者，并分为持续性变应性鼻炎，嗜酸性粒细胞增多综合征（NARES）的非变应性鼻炎和伴息肉的慢性鼻-鼻窦炎。招募非流鼻血的志愿者作为对照。通过“ Quantikine人类CCL24免疫测定”测量CCL24浓度。通过显微镜下细胞学检查下鼻甲刮下的鼻腔组织进行差异细胞计数。结果：与NARES患者中最高水平的对照组相比，患者组中测量的CCL24水平显着高于对照组。嗜酸性粒细胞趋化因子-2水平与症状的严重程度以及鼻腔组织中嗜酸性粒细胞的百分比显着相关。结论：我们发现所有患者组中的CCL24水平高，与嗜酸性粒细胞增多程度和临床症状密切相关。鼻粘膜中CCL24的长时间积累可能会维持这些患者的非特异性自我永存性嗜酸性粒细胞募集性病理过程。

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