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首页> 外文会议>Asia Pacific Congress of Allergology and Clinical Immunology >Nasal Fibroblasts Produce Chemokines and Adhesion Molecules for Eosinophils in Patients with Chronic Rhinosinusitis
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Nasal Fibroblasts Produce Chemokines and Adhesion Molecules for Eosinophils in Patients with Chronic Rhinosinusitis

机译：鼻成纤维细胞产生慢性鼻窦炎患者的嗜酸性粒细胞的趋化蛋白和粘附分子

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Eosinophilic chronic rhinosinusitis (ECRS) is characterized by a marked accumulation of activated eosinophils in local mucosa. However, it is not yet clarified whether fibroblasts in ECRS have different characteristics from those in non-eosinophilic chronic rhinosinusitis (NECRS). We compared the production of important factors for eosinophil migration for fibroblasts cultured from patients with those two conditions. The only difference found was that eotaxin production from fibroblasts derived from ECRS was significantly higher than that from NECRS fibroblasts. Our results suggest that ECRS fibroblasts produce greater amounts of eotaxin in response to TNF-alpha and IL-4, which may be one of the mechanisms of tissue eosinophilia in ECRS.
机译：嗜酸性慢性鼻窦炎（ECRS）的特征在于局部粘膜中的活化嗜酸性粒细胞的显着积累。然而，尚不澄清ECRS中的成纤维细胞是否具有与非嗜酸性慢性鼻窦炎（NECR）中的成纤维细胞具有不同的特征。我们比较了从患者培养的两种条件培养的成纤维细胞迁移的重要因素。发现的唯一差异是从ECRS衍生的成纤维细胞产生的Eotaxin产生显着高于来自NeCrs成纤维细胞的成纤维细胞。我们的结果表明，ECRS成纤维细胞响应于TNF-α和IL-4产生更多的ETAXIN，其可以是ECRS中组织嗜酸性粒细胞的机制之一。

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