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首页> 外文期刊>Cellular Physiology and Biochemistry >Maternal perinatal undernutrition attenuates T-cell function in adult male rat offspring
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Maternal perinatal undernutrition attenuates T-cell function in adult male rat offspring

机译：母体围产期营养不良会削弱成年雄性大鼠后代的T细胞功能

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Objective.We investigated the impact of maternal food restriction during gestation and lactation on the number and function of peripheral T cells in adult male offspring. Study design. Pregnant rats either received ad libitum (control) feed or were 50% food restricted (FR) from day zero of gestation to delivery and during the lactation period. After weaning, pups from control and FR mother rats were fed normally until they reached 8 weeks of age. At 8 weeks of age, blood parameters, plasma cytokine levels, and T cell number and function were determined in 10 male offspring from each group. Results. FR offspring exhibited decreased numbers of total and CD4+ and CD8+ T lymphocytes and a significant reduction in plasma IL-2 and IL-7 compared with control offspring. In addition, T lymphocytes from FR offspring exhibited a 2-fold decrease in IL-2- and IL-7-mediated AKT and STAT5 phosphorylation, altered actin polymerization, and diminished superantigen-mediated proliferation and cytokine production as compared with control offspring. Conclusions.aken together, these findings suggest that early undernutrition, particularly during the prenatal and lactation periods, attenuates T cell survival and the immune response.
机译：目的。我们研究了孕期和哺乳期母体食物限制对成年雄性后代外周T细胞数量和功能的影响。学习规划。从妊娠的第零天到分娩以及在哺乳期，怀孕的大鼠可以随意接受（对照）饲料，或者接受50％的食物限制（FR）。断奶后，正常喂养对照组和FR母鼠的幼崽，直到它们达到8周龄。在8周龄时，从每组的10个雄性后代中测定血液参数，血浆细胞因子水平以及T细胞数量和功能。结果。与对照组相比，FR后代的总淋巴细胞和CD4 +和CD8 + T淋巴细胞数量减少，血浆IL-2和IL-7显着减少。此外，与对照后代相比，FR后代的T淋巴细胞的IL-2-和IL-7介导的AKT和STAT5磷酸化降低了2倍，肌动蛋白聚合改变，超抗原介导的增殖和细胞因子生成减少。结论综上所述，这些发现表明，早期营养不良，尤其是在产前和哺乳期，会降低T细胞存活率和免疫反应。

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