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首页> 外文期刊>Rheumatology >Employment and work disability in systemic lupus erythematosus: a systematic review.
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Employment and work disability in systemic lupus erythematosus: a systematic review.

机译：系统性红斑狼疮的就业和工作残疾：系统评价。

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OBJECTIVES: Many studies have provided information on employment and work disability (WD) rates in patients with SLE, yet are often limited by small sample sizes, poor generalizability or fail to examine the risks and outcomes of WD. Our objective was to systematically review the literature on WD in SLE to identify a more generalizable point estimate and range of WD in SLE patients. METHODS: A search was conducted using Medline, EMBase, PubMed and Cochrane databases to identify publications related to SLE and employment and/or WD. Characteristics of the study samples and employment/WD data were extracted. Descriptive statistics, a test for heterogeneity and random effects models were performed to obtain pooled estimates of employment and WD rates for all patients. RESULTS: Twenty-six studies with a total of 9886 SLE patients were found; however, not all patients were reviewed for WD. Larger studies demonstrated the prevalence of WD at 20-40%, and pooled estimates found that 46% (95% CI 40%, 52%) were employed with SLE and 34% (95% CI 24%, 44%) had WD. WD was related to psychosocial and disease-related factors including age, race, socioeconomic status (SES), education, disease activity and duration, pain, fatigue, anxiety and neurocognitive involvement. CONCLUSIONS: This study provides strong evidence that costs of SLE may be very high due to job loss at a younger age in SLE patients, and identifies some risk factors associated with WD, which should be targeted by interventions aimed at preventing job loss.
机译：目的：许多研究已经提供了有关SLE患者的就业和工作残疾（WD）率的信息，但通常受限于样本量小，通用性差或无法检查WD的风险和结果。我们的目标是系统地回顾SLE中WD的文献，以确定SLE患者更广泛的点估计和WD范围。方法：使用Medline，EMBase，PubMed和Cochrane数据库进行搜索，以鉴定与SLE，就业和/或WD相关的出版物。提取研究样本的特征和就业/ WD数据。进行描述性统计，异质性检验和随机效应模型，以获取所有患者的就业和WD率的汇总估计。结果：共进行了26项研究，共9886名SLE患者;但是，并非所有患者都接受了WD复查。更大的研究表明WD的患病率为20-40％，汇总估算发现SLE占46％（95％CI 40％，52％），而WD占34％（95％CI 24％，44％）。 WD与社会心理和疾病相关的因素有关，包括年龄，种族，社会经济地位（SES），教育程度，疾病活动和持续时间，疼痛，疲劳，焦虑和神经认知受累。结论：这项研究提供了有力的证据，表明由于SLE患者年轻时的失业导致SLE的成本可能很高，并确定了与WD相关的一些危险因素，应采取预防失业的干预措施作为目标。

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